HIV pipeline report 2021: new drugs in development

Simon Collins, HIV i-Base

For all the focus and difficulties over COVID-19, this year is still an exciting year for HIV pipeline research.

This short report, produced as an i-Base supplement, references 120 papers on key developments over the last 14 months.

It is also updated to include results presented at the IAS 2021 virtual conference.


  1. Introduction: pipeline after COVID-19
  2. Update to the viral lifecycle
  3. Summary over the last year
  4. Update from IAS 2021 conference
  5. Recent approvals and submitted applications
  6. Drugs in phase 2/3 development
  7. HIV bNAbs
  8. Other compounds
  9. Discontinued drugs
  10. Conclusion
  11. References