I’m resistant to my meds, what should I do?
2 September 2019. Related: All topics, CD4 and viral load, Changing treatment.
Hi, I’ve been on treatment (Atripla) for 8 months (after acute infection in august last year)
In march my viral load were 1200, so the doctor ask to wait 2 months and test again.
After 2 months in May my VL was 1007. Due to my viral load still being detectable my doctor ordered some resistance tests.
I took the test in June and got my results back in August. From the three components of Atripla, two of them were highly resistant, only the tenofovir is partially resistant. My VL was 840.
What should I do in this situation?
Thanks for getting in touch.
From what you’ve said it sounds likely that you might have the resistance strain M184V for the 3TC and K103N for the efavirenz. Tenofovir partial resistance could be any thymidine analogue mutation.
Either way, with this resistance report, changing the efavirenz is essential. M184V resistance is sometimes okay to keep (ie continuing 3TC is sometimes ok) because it makes HIV less fit.
Changing to second like – ideally dolutegravir + two nukes would be recommended in the UK, while your VL is still low.
This is something that you’re going to need to discuss with your doctor.