Question

What is the difference between TLD, Tribuss and Aluvia+Zovilam?

4 January 2021. Related: All topics, Changing treatment, Starting treatment.

Hi. What is the difference between Tribuss and aluvia+zovilam?

Thank you

Answer

Answer: Simon Collins

Hi

These are three main combinations used to treat HIV across the world.

Each one contains a different combination of three active HIV drugs.

TLD stands for tenofovir D + lamivudine + dolutegravir.

This is the most recent combination. The biggest difference is that dolutegravir is an integrase inhibitor. It works more quickly and has even fewer side effects than other combinations. All guidelines now recommend integrase inhibitors as the first combination.

Tribuss contains tenofovir D + emtricitabine + efavirenz.

Tribuss was the most recommended first-line combination for many years. It is still used in most low income countries, although people are steadily moving to use TLD instead. Since integrase inhibitors were developed, it has become rarely used in high income countries. This is because efavirenz has more side effects than dolutegravir.

Aluvia+Zovilam is lopinavir/ritonavir + AZT/lamivudine.

Lopinavir/ritonavir is a boosted protease inhibitor. AZT is a much older version of a nuke (similar to tenofovir). This combination was widely used as second-line treatment after people developed drug resistance to Tribuss.