Question
Long term side effects from PEP.
24 January 2022. Related: All topics, PEP/PEPSE, Side effects.
I took PEP (Truvada and Isentress) five times in the last 10 years for 21 to 28 days each time. My doctor treated them as very safe and I suffer from anxiety, so it was prescribed after every situation of low risk with someone of unknown status. I’m a heterosexual male in my 40s, I have read the side effects which include bone density loss, kidney problems and even cancer from Isentress. Do you see those side effects could present in my case? Will these drugs affect my genetic material if I want to have kids? My kidneys are filtering 10% under average for my age but can’t prove that it wasn’t like that before taking these meds. Thank you for your help!
Answer
Hi, how are you doing?
The side effects you have mentioned are associated with these medications when on long-term use. Having 5 courses of 10 years is not going to lead to these complications. Your doctor was right to treat the course of PEP as safe.
During PEP side-effects are often noted to be short term and resolve when the course ends. There will have been no long-term effect to your genetic material. You are safe to have children.
Truvada is linked to kidney function loss. However, this is assessed long term and can present within 6 months of starting. In your case you were not on it longer than 28 days at a time. Are you aware of of any kidney problems you had before starting PEP? Filtering 10% under average does not indicate loss of function. As it’s an average many people will fall into the same bracket as you are are very healthy.
Josh.
Hi Victor, after a year you would not experience any side effects form treatment you had last year. Even though the symptoms are similar, PEP is not the cause and you should speak to a doctor for investigations about what else is causing these problems you currently have.
Hi I took pep last year almost at this same period..the side effects.. disappeared but for now almost one year..it seems the same side effects are coming back .. only the rush and no any other effects..what could be the problem
Hi Xxx, as this is severe pain have you gone to see your doctor about this?
What is the name of the PEP you are taking? and how long after taking PEP are you experiencing this pain?
For more information about PEP please see here: https://i-base.info/qa/factsheets/pep-faq
I’ve been taking Pep for 4 days now. I am feeling severe pain in my stomach. Had a vaginal sex and the condom broke with an unknown status person. Now I am feeling pain in my stomach when taking Pep especially night hours
Hi Junior, what is the name of the PEP you are taking? and is this PEP or PrEP?
PrEP is a 2-drug combination and is used to prevent exposure before sex whereas PEP is used after an exposure. PEP is a 3-drug combination and is more similar to HIV treatment.
PrEP: https://i-base.info/guides/prep
PEP: https://i-base.info/qa/factsheets/pep-faq
As with all skin changes you should go to a doctor for these changes to be examined. Have these rashes only started recently or have they been present for the 6 months you have been taking this medication?
I have been taking pep for 6 month because I have been have sexual intercourse with my girl who is hiv positive but now am starting to have skin rushes at my back and stomach and legs