Question
Can switching from Trenvir have caused my mood disturbances?
28 April 2023. Related: All topics, Changing treatment, Side effects.
I requested to be switched from Trenvir due to being ever depressed, skin flabbing and no appetite. The doctor put me on combination of tenofovir+emtricitabine+rilpivirine. I also take hormone and hypertension meds. Now I only sleep for 3 hours, then am awake for the rest of the night. Could this be side effects of the new treatment? I am still battling with depression and mood swings.
Answer
Hi, how are you doing?
I am sorry to hear that you are still battling with depression and having mood swings.
Has anything changed since switching treatment? Have the mood swings got less? Is the depression worse? Are you sleeping differently?
Rilpirivine can cause mood disturbances. Did your doctor suggest any other treatments?
When did these mood symptoms start? Did you experience them before starting Trenvir or has it been since starting HIV treatment?
How are you manaing with your mood symptoms? Have you been offered any talking therapies, psychological assistance or have you considered taking anti-depressants?
Trenvir does not commonly cause the symptoms you initially mentioned. Usually the most common are weight gain and poor sleep. Taking it in the morning can help prevent its effects on sleep.
Josh.
Hello Francois and thanks for getting in touch.
I am sure you have tried, but the best time to take Volutrip is in the morning.
Can I also ask how old are you?
Peri-menopause (the years leading up to menopause, which can start as early as 40 years old) can also affect your sleep.
I am sure you will find yourself what helps or not but please see the below links for some advice that might help you sleep better:
– Notice how much caffeine you drink (tea, coffee, coke, energy drinks, etc. and try to limit it. Don’t drink any drinks with caffeine after 16.00
– practice sleep hygiene before going to bed:
https://www.nhs.uk/every-mind-matters/mental-wellbeing-tips/how-to-fall-asleep-faster-and-sleep-better/
– guide to managing insomnia:
https://i-base.info/guides/side/insomnia-disturbed-sleep
Good day. I switched from Trenvir to Volutrip after 3yrs. I’m struggling to fall asleep now. No matter what time period I take the Volutrip. Since day 2 on it. Also skin irritation. Please advise me on this.
(Volutrip is the drug available at your govt clinics. My medical aid was terminated, so I only have the govt as back up )