Question
Can I do on-demand PrEP as 1-1-1 dosing?
16 July 2023. Related: Adherence, All topics, PrEP.
Weekly on-demand PrEP dosing?
I tend to have sex on Fridays nights. Is a double dose required when restarting on-demand PrEP on Friday mornings when the last previous dose was on Sunday?
Different pages on your website say different things about gaps of less than 7 days. Obviously a 2-1-1 pattern is needed for gaps of longer than a week, but it is unclear whether 1-1-1 is possible if taken weekly.
Answer
Hi, how are you doing?
In most cases it is fine to do this once e.g., complete the first regimen of on-demand dosing using a double dose, then restarting with a single dose within 7 days.
However this is usually on suggested as a one-off thing and not to be repeated.
Doing this regularly on a 1-1-1 dose means you are only using PrEP 3/7 days on a single dose. Not suing that initial double dose can reduce the required initial level of PrEP in your body – this is accounted for by repeating the regimen once.
For this reason it would either be recommended to always use a double dose on the Friday if you want to continue on-demand, or move to a daily regimen and build PrEP into your daily routine.
Josh.
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