Question

How do I take supplements without them interacting with my ARVs?

2 August 2023. Related: All topics, Drug interactions.

Hi I-base, I am a 42 years old man, recently found out that I am HIV positive. I have been given ARVs(dolutegravir,lamivudine and tenifovir),which I have to consume 1 tablet a day, every day at 1pm…but I want to add some supplements like zinc, magnesium, vitamin D3, K2, B-complex and vitamin C. Can you please advise me on time frame to take these supplements so that it does not interact with the ARV?

Answer

Answer: Josh Peasegood

Hi, how are you doing?

You have been given a combination of ARVs called TLD. As TLD contains dolutegravir there is some risk of interaction between the supplements you have mentioned.

Zinc and magnesium are able to interact with dolutegravir. When taken together these supplements can prevent how much dolutegravir is absorbed by the body.

To avoid this you need to take your supplements either 2 hours before or 6 hours after dolutegravir. In your case this mean taking them at either 11am (or earlier) or 7pm (or later). Leaving this amount of time means your medications will not interact.

Josh.