Question
Can PEP cause skin reactions?
2 September 2024. Related: All topics, PEP/PEPSE, Side effects.
Is Truvada or Tivicay known to cause allergic reactions? For example, redness of skin to face chest neck. I am taking these for HIV PEP. Reactions started approximately ten days into regimen and I tested HIV negative before starting PEP.
Answer
Hi there
PEP meds are chosen because they generally have a low risk of side effects.
However, rare skin reactions can occur to many different drugs and it is important that any rash is seen by a doctor.
The doctor can then decide whether it is better to use different meds as PEP.
This link has more info on PEP, including possible side effects.
https://i-base.info/qa/factsheets/pep-faq

Hello Klaus and thanks for getting in touch.
This is a service for people living with HIV who need more information on their medication.
Please see here for the risk of transmission
Please see here for more information on seroconverion.
Finally, you, like most people, forget that there are other infections and bugs out there.
I would recommend having a full sexual health screen (including gonorrhoea, syphilis, chlamydia, etc.) 6 weeks after you finish PEP
That will tell you whether you picked up something or not definitively. The window period for syphilis is 3 months though.
Hello
I tested negative at the beginning of treatment.Is it possible to develop symptoms in November when i finished treatment in june 2025. Now in November i have started feeling tired, pain in joints and itch skin only no other symptoms