Question
Does a late third dose on 2:1:1 PrEP mean I need PEP?
26 March 2026. Related: Adherence, All topics, PrEP.
Hi – I’m on the 2-1-1 on-demand PrEP regimen: I took 2 tablets at time 0 (the initial loading dose), then 1 tablet at 32 hours (8 hours late, instead of the scheduled 24-hour dose), then 1 tablet at 48 hours. I plan to take one more tablet at 7 PM this afternoon.
I had unprotected receptive anal intercourse, where I was the receptive partner (the one being penetrated). The other person inserted for only 5 minutes, but there was a brief moment of fast penetration right at the start that caused me pain once. I don’t know his HIV status and he did not ejaculate.
Do I need to start PEP as my third PrEP dose was taken 8 hours late?
Answer
Hi there
Please do not worry about this.
The following information should help you decide on the need for PEP.
- This doesn’t sound like any risk for HIV?
- The initial double dose provides very good drug levels to cover slightly later doses.
- The doses afterwards would still have covered you well.
Based on this situation, UK guidelines would include any need to use PEP.
Please these links for info on PrEP and PEP:
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