Question
Can I switch to take meds in the morning instead of the evening?
18 December 2011. Related: Adherence, All topics.
I have just started treatment this week on a combination of truvada, ritonavir and atazanavir.
I have started taking them in the evening but with my work I now think moving to taking them at breakfast would be easier.
Can I just start doing that or is it more complicated than that now I’ve started?
Answer
Hi
There is a lot of flexibility in timing to find what works best for you.
With the meds in your combination is also easy to switch from evening to morning. Take your last evening dose at the usual time, and then take another dose the next morning at the time you want to take them. You are doing this to make sure you never leave more than 24 hours between doses, when the drug levels could drop too low and risk resistance.
Your drug levels will be slightly higher for the first few hours of dose the next day. This is unlikely to be a risk because there is already a wide range of variability in drug levels achieved by different people.
If you are worried about this, your last evening dose could be taken without the ritonavir, but this might be unecessarily cautious.
The only meds that really need to be taken at night are efavirenz and rilpivirine, or the combined pills that include these meds (Atripla and Complera).
Your HIV pharmacist would also be able to talk to you about this on the phone if you want to check this with the clinic first.
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