Question
Can I use lamivduine as PEP?
3 January 2022. Related: All topics, Changing treatment, PEP/PEPSE.
I was given lamuviduine 10×100 mg after a condom slip with someone who is HIV positive. After the first 10 doses, they gave me 150 mg.
Does it have anything to do with the medication?
Answer
Hi how are you?
Post-exposure prophylaxis (PEP) should be a combination of three different medications. Lamivudine is often one but it requires another 2 medications to be taken alongside it. The most highly recommend combination by WHO guidelines is lamivudine + dolutegravir + tenofovir.
It is not recommended to be on a single medication for PEP. PEP also does not change dose midway through a course. A course of PEP lasts for 28 days for it to be effective.
Josh.
Hi Kay, yes this combination can work without tenofovir. PEP is often recommended as a 3-drug regimen however a 2-drug regimen is suitable. The evidence base for the additional third drug is limited with not much supporting how much it increases the effectiveness of PEP. You will be safe to take the lamivudine/dolutegravir regimen that you have been given.
As the condom was in tact this is a low risk exposure.
For more information about PEP please see here: https://i-base.info/qa/factsheets/pep-faq
Hi, I had a mid-low exposure. The condom looked intact but I could not see any spern in the condom. I went to the Dr and got pills that have lamidivine and Dolutegravir. Can the do drug combination work without tenovit