Question

Do I need PEP if I was later with on-demand PrEP?

9 June 2022. Related: Adherence, All topics, PrEP.

Has my PrEP on-demand failed due to the delay of taking the second dose?

Hi all. Today I should take the second dose of PrEP pills for 2-1-1 PrEP on-demand. But I delayed and took the second dose after 2 hours I should take. (1st day 2 pills on 1pm but I took the second dose on 3 pm next day).
Will this still work and should I start PEP immediately due to the delay of taking the second dose in 2-1-1 PrEP on demand?

I feel worried and thank you for your answers.

Answer

Answer: Josh Peasegood

Hi, how are you doing?

You do not need to take PEP. PrEP will still be effective in this case.

The first double dose will allow for you being late with the 2nd dose for a few hours. This is because there will be a high enough concentration of medication within your body to account for the late dose.

2 hours late will not effect how well PrEP works.

Josh.