AIDS-defining infections for CDC clinical categories

Conditions included in the 1993 CDC AIDS surveillance case definition were laast updated in 2008.

The few changes are underlined in the list below.*

• Bacterial infections, multiple or recurrent *
• Candidiasis of bronchi, trachea, or lungs.
• Candidiasis, esophageal (thrush) – but not mouth.
• Cervical cancer, invasive.
• Coccidioidomycosis, disseminated or extrapulmonary.
• Cryptococcosis, extrapulmonary.
• Cryptosporidiosis, chronic intestinal (greater than 1 month’s duration).
• Cytomegalovirus disease (CMV) (other than liver, spleen, or nodes).
• Cytomegalovirus retinitis (CMV) (with loss of vision).
• Encephalopathy, HIV-related.
• Herpes simplex: chronic ulcer(s) (greater than 1 month’s duration); or bronchitis, pneumonitis, or esophagitis.
• Histoplasmosis, disseminated or extrapulmonary.
• Isosporiasis, chronic intestinal (greater than 1 month’s duration).
• Kaposi’s sarcoma (KS).
• Kaposi sarcoma^†
• Lymphoid interstitial pneumonia or pulmonary lymphoid hyperplasia complex*
• Lymphoma, Burkitt’s (or equivalent term).
• Lymphoma, immunoblastic (or equivalent term).
• Lymphoma, primary, of brain.
• Mycobacterium avium complex or M. kansasii, disseminated or extrapulmonary.
• Mycobacterium tuberculosis (TB), any site (pulmonary or extrapulmonary).
• Mycobacterium, other species or unidentified species, disseminated or extrapulmonary.
• Pneumocystis jirovecii pneumonia (PCP)– formerly pneumocystis carinii).*
• Pneumonia, recurrent.
• Progressive multifocal leukoencephalopathy (PML).
• Salmonella septicemia, recurrent.
• Toxoplasmosis of brain.
• Wasting syndrome due to HIV.

Source: Center for Disease Control (CDC) –  MMWR (2008)

Last updated: 1 January 2023.