Medscape articles

From: AIDS Reader

Where Now for Trizivir? – Role of the Triple-NRTI Pill Post-ACTG 5095
Graeme J. Moyle, MD, MBBS
Triple NRTI therapy should be avoided as sole initial therapy.
Histoplasmosis in a patient with AIDS
http://mp.medscape.com/cgi-bin1/DM/y/hb860F74sn0D1P0Faxk0AS

Long-term complications of nucleoside reverse transcriptase inhibitor therapy
Douglas Dieterich MD
Review of the major long-term complications associated with NRTIs: hyperlactatemia and lactic acidosis/hepatic steatosis, other hepatotoxicities, pancreatitis, lipodystrophy/lipoatrophy, neuropathy, and haematologic toxicities.
http://mp.medscape.com/cgi-bin1/DM/y/hb860F74sn0D1P0FaxI0AT

From: American Journal of Clinical Pathology

Toxic effects of nucleoside reverse transcriptase inhibitors on the liver
The authors demonstrate that NRTI-induced toxic effects in the liver may occur as indolent nonspecific disease with variable histologic features and emphasises the diagnostic value of electron microscopy, particularly when diffuse steatosis is absent.
http://mp.medscape.com/cgi-bin1/DM/y/hb860F74sn0D1P0Faxj0AR