19th Conference on Retroviruses and Opportunistic Infections (CROI), 5-8 March 2012

1 April 2012. Related: Conference reports, Conference index, CROI 19 (Retrovirus) 2012.

Introduction

The Conference on Retroviruses and Opportunistic Infections (CROI) conference is probably the most important annual scientific HIV meeting and it is also one of the most accessible for people who are unable to attend the meeting.

Most of the presentations are available to watch free online without registration. This includes web casts of the opening lectures, oral presentations and poster discussions.

Abstracts and PDF files for many of the full posters are also online.

http://retroconference.org

With over 1100 studies presented, we will split coverage over two issues of HTB. This issue includes reports on cure research, antiretrovirals, paediatrics, prevention studies and some hepatitis coinfection. The next issue will include PMTCT, women’s health, treatment access, TB, opportunistic infections, side effects and other complications. Some of these early reports will be posted online prior to the print edition.

This issue includes:

• Cure research takes centre stage: proof of concept for activating the latent reservoir

• Quad fixed-dose integrase combination: phase 3 studies at week 48

• Dolutegravir studies continue to show promise

• Tenofovir prodrug: 10 day monotherapy study sets dose at 25 mg for easier coformulation

• Paediatric formulations of ARVs: including an exciting new class

• Lower malaria risk in children receiving lopinavir/ritonavir-based compared to NNRTI-based ART

• High prevalence of d4T-associated lipodystrophy including lipoatrophy in children

• Lopinavir/ritonavir monotherapy in children

• Stopping treatment after early ART in infants

• PrEP: PK modeling of daily TDF/FTC (Truvada) provides close to 100% protection against HIV infection

• Risk of HIV reinfection may be similar to risk of initial HIV infection

• Case report: homozygous CCR5 delta-32 protection overcome by infection with X4 virus

• No association between atazanavir and MI or stroke in D:A:D study

• Hepatitis C coinfection studies

• Herpes Zoster vaccine safe and effective in HIV positive people

• High dose flu vaccine improves antibody responses in HIV positive people