April 2012

Contents

Editorial

• Volume 13 Number 3/4 March/April 2012

Special reports

• Supplement: i-Base Introduction to Combination Therapy

Conference reports

• 19th Conference on Retroviruses and Opportunistic Infections (CROI), 5-8 March 2012

• Cure research takes centre stage: proof of concept for activating the latent reservoir

• Quad fixed-dose integrase combination: phase 3 studies at week 48

• Dolutegravir studies continue to show promise

• Tenofovir prodrug: 10 day monotherapy study sets dose at 25 mg for easier coformulation

• Paediatric formulations of ARVs: including an exciting new class

• Lower malaria risk in children receiving lopinavir/ritonavir-based compared to NNRTI-based ART

• High prevalence of d4T-associated lipodystrophy including lipoatrophy in children

• Lopinavir/ritonavir monotherapy in children

• Stopping treatment after early ART in infants

• PrEP: PK modeling of daily TDF/FTC (Truvada) provides close to 100% protection against HIV infection

• Risk of HIV reinfection may be similar to risk of initial HIV infection

• Case report: homozygous CCR5 delta-32 protection overcome by infection with X4 virus

• No association between atazanavir and MI or stroke in D:A:D study

• Hepatitis C coinfection studies

• Herpes Zoster vaccine safe and effective in HIV positive people

• High dose flu vaccine improves antibody responses in HIV positive people

Antiretrovirals

• Dolutegravir Expanded Access Programme

• FDA approves etravirine for treatment-experienced children 6 to 18 years of age and new scored 25 mg tablet for paediatric dosing

Treatment access

• Global action over the challenge to India

• Why global health activists are fired up about Novartis

• Obama’s global, domestic & HIV research budget backslides on existing commitments

PK and drug interactions

• FDA warning of drug interactions between boceprevir and some HIV protease inhibitors

Guidelines

• US HHS adult treatment guidelines updated (March 2012)

Side effects

• FDA reject capsaicin patch for HIV-related neuropathy

Other news

• Free comic book for HIV positive children about CD4, viral load and ARV treatment

On the web

• Free full text online articles

PDFs

• Volume 13 Number 3/4 March/April 2012 PDF