Countries with lower HIV prevalence have lower ART coverage
Polly Clayden, HIV i-Base
Low- and middle-income countries with adult HIV prevalence less than 5% had significantly lower rates of ART coverage in adults, pregnant women and children than those with higher prevalence. Lower prevalence countries also had a smaller percentage of women attending antenatal (ANC) visits and early infant diagnosis (EID) for infants.
Andrew Hill and colleagues from Liverpool University; Chelsea and Westminster Hospital; Imperial College; University of Oxford; World Health Organisation and UNITAID presented this analysis at CROI 2016.
They used data from the UNAIDS 2014 database that includes country-level information on epidemic size, HIV prevalence, ART coverage, ANC visits and EID. They noted that higher prevalence countries (at least 5%) are prioritised in PEPFAR and Global Fund ART programmes but 50% of HIV positive people live in lower prevalence countries.
Fifty-two low- and middle-income countries with at least 50,000 HIV positive people were included in the analysis: 40 with less than 5% HIV prevalence (total 16 million HIV positive) and 12 at least 5% HIV prevalence (total 16.1 million HIV positive).
The investigators used least squares linear regression to correlate adult HIV prevalence with estimated rates of ART coverage (adults, pregnant women and children), ANC, and EID. They weighted the analysis by epidemic size and controlled for GDP/capita and region (African vs non-African countries).
They found lower prevalence countries to have significantly lower rates of treatment coverage in adults, pregnant women and children, p<0.01 for each comparison. Lower prevalence countries also had a smaller percentage of women attending ANC visits and EID for infants than higher prevalence ones, p<0.01. See Table 1.
(<5% HIV+ adults)
(>5% HIV+ adults)
|HIV epidemic size||16 million||16.1 million|
|Adult HIV prevalence||1.6%||14.6%|
|Adults on ART||31.7%||48.3%|
|Children on ART||22.4%||42.6%|
|Pregnant women on ART||46.7%||89.1%|
|Pregnant women with > ANC||55.3%||68.1%|
|Infants received EID||20.1%||72.3%|
|Annual HIV death rate||4.5%||2.5%|
|Annual HIV transmission rate||6.2%||5.4%|
The annual death rate for HIV positive people was 4.5% in the lower prevalence countries compared with 2.5% in the higher prevalence countries. The respective HIV transmission rates were 6.2% and 5.4%.
The investigators acknowledged a subset of lower prevalence countries with high rates of HIV testing and ART coverage eg Thailand, Rwanda, Vietnam and Dominican Republic. But many other lower prevalence countries need to prioritise HIV testing and ART for adults, pregnant women and children eg Russia, China, Nigeria, India and Pakistan, they wrote.
Hill A et al. Countries with lower HIV prevalence have lower ARV coverage: UNAIDS 2015 database. Conference on Retroviruses and Opportunistic Infections (CROI) 2016. 22-25 February 2016. Boston, Massachusetts. Poster abstract 1023.