HTB

CROI 23 (Retrovirus) 2016

23rd Conference on Retroviruses and Opportunistic Infections (CROI 2016), 22-25 February 2016, Boston

No effect of tenofovir on infant bone mineral content in African study

Use of modelling to predicting paediatric dosing of long acting antiretrovirals

Nevirapine dosing for treatment of neonates

START substudies: increased quality of life from earlier treatment but no impact on vascular function or cardiovascular markers

Six-week ledipasvir/sofosbuvir in HIV positive patients with acute HCV

23rd Conference on Retroviruses and Opportunistic Infections (CROI 2016), 22-25 February 2016, Boston

Dual long-acting injections of cabotegravir plus rilpivirine: 32-week results from LATTE-2 study

New NRTI MK-8591 (EFdA): weekly oral dosing and once-yearly slow-release dosing has potential for HIV treatment and PrEP

48-week results for NNRTI doravirine compared to efavirenz

Dramatic increase in use of oral TDF/FTC for PrEP in the US – plus a few cautions

Future oral and long-acting formulations for PrEP: pills, films, gels, injections and depots

First data on TAF as PrEP to prevent HIV infection

Long-acting cabotegravir as PrEP protects macaques against IV exposure but will need two-monthly injections

Role for maraviroc as HIV PrEP likely to need dual combinations

Dapivirine PrEP vaginal ring shows only limited PrEP protection against HIV in African women

Early data from dolutegravir use during pregnancy

Dolutegravir: 48 week results in children age 6 to 12 years old

New antiretrovirals could mean savings up to US $3 billion by 2025

Countries with lower HIV prevalence have lower ART coverage

Nigerian herbal medicines widely used by HIV positive people can contain antiretrovirals

Cure research news from CROI 2016