PRO-542 shows efficacy in trial
16 September 2000. Related: Antiretrovirals.
Polly Clayden, HIV i-Base
A report in the July issue of the Journal of Infected Diseases of a phase 1 study of PRO 542 – a recombinant antibody-like fusion protein that binds to and neutralises HIV-1 isolates, showed significant viral load reduction, good tolerability and no dose limiting toxicities, in HIV-infected adults.
Subjects were treated with a single intravenous infusion of PRO 542 at doses of 0.2-10 mg/kg. The drug was well tolerated, and the AUC and peak serum concentrations increased linearly with the dose, as did reduction in HIV-1 RNA. No patient developed antibodies to PRO 542.
Sustained antiviral effect may be achieved with dosing of PRO 542. This novel agent deserves further investigation.
Reference:
Single dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults. Jacobson et al. J of Infect Dis 2000 Jul; 182(1):326-9