Outcomes from COVID-19 in French cohort of 54 HIV positive people on ART
Simon Collins, HIV i-Base
A research letter published in the 1 October 2020 edition of AIDS reported results from a prospective observational study in Paris in HIV positive people who were on ART with generally good CD4 counts. 
The study included 54 HIV positive adults (60% men) diagnosed with COVID-19 from 1 March to 30 April 2020.
Median age was 54 years (IQR: 47 to 60) and median CD4 counts was 583 cells/mm3 (IQR: 474 to 773). All were on ART and nearly all (51/53) had viral load <40 copies/mL.
Over median of 29 days (IQR: 29 to 45 days), all for at least 14 days, 35/54 (65%) developed moderate disease, 14/54 severe (26%) and 5/54 were critical (9%). One person died.
Participants from Sub Saharan Africa were disproportionally affected compared to the clinic population overall (45% vs 30%), with higher rates of severe disease (13/19 vs 13/35).
By multivariate analysis, age , male gender, ethnic origin from Sub Saharan Africa, and metabolic disorder, were associated with severe or critical forms of COVID-19.
Prior CD4 T cell counts did not differ between groups.
The disproportionate impact of ethnicity on COVID-19 infection and outcomes is increasingly reported, including in the US and UK. [2, 3]
- Etienne N et al. HIV infection and COVID-19 risk factors for severe disease. Research letter. AIDS: 2020; 34(12):1771-1774. DOI: 10.1097/QAD.0000000000002651. (1 October 2020).
- Meyerowitz EA et al. Disproportionate burden of COVID-19 among racial minorities and those in congregate settings among a large cohort of people with HIV. AIDS. 2020 Oct 1; 34(12): 1781–1787.
- Coronavirus (COVID-19) related deaths by ethnic group, England and Wales – Office for National Statistics.