October 2020

Contents

Editorial

• HTB: no. 11 – HIV and COVID-19: issue 8 (14 October 2020)

In memory

• In memory: Timothy Ray Brown – the Berlin patient, the first person to be cured of HIV

Conference reports

• HIV Therapy Glasgow 2020

• Capsid inhibitor lenacapavir, dosed six-monthly, has high barrier to drug resistance and no cross-resistance to other classes

• Single doses of MK-8507 reduce viral load by mean –1.5 log and support once-weekly dosing above 80 mg

• Weight gain with dolutegravir-based ART in Nigerian cohort

• COVID-19: pathogenesis and treatment 

• EACS guidelines updated (v.10.1) for Glasgow conference

• International Workshop on Clinical Pharmacology of HIV, Hepatitis, and Other Antiviral Drugs

• FTC exposure higher in young transgender men than cisgender controls

• Levels of long-acting anti-HIV bNAb high in infants after 1 or 2 doses – but not high enough

Guidelines

• BASHH 2020 PEP guidelines: online for comment

Cure-related research

• New insights into elite control of HIV and a possible case of virus clearance

COVID-19: HIV and COVID-19 coinfection

• US study of HIV positive people with COVID-19 reports worse outcomes with comorbidities and having a CD4 <200

• Outcomes from COVID-19 in French cohort of 54 HIV positive people on ART

• Oxford COVID vaccine enrolling HIV positive people at two London sites

COVID-19: investigational drugs

• Tocilizumab fails to meet clinical endpoints in randomised COVACTA study: other studies continue

COVID-19: paediatrics

• COVID-19 deaths in children and people <21 years old in the US

COVID-19: pathogenesis

• Long COVID: Mild infection and sustained long-term complications

COVID-19: guidelines

• BHIVA update guidance for HIV care during second wave of COVID-19

COVID-19: transmission & prevention

• COVID-19 reinfection can occur after varying times and with more severe disease

• Transmission from children to family members in US childcare setting

COVID-19: diagnostics

• IDSA guidelines on serologic testing for SARS-CoV-2

COVID-19: other news

• Review paper highlights substandard COVID-19 research in both peer-review journals and pre-review websites