Research approach to rapidly review candidate treatments for COVID-19: nine studies using ACTIV protocol
Simon Collins, HIV i-Base
This paper outlines a research approach to the urgency needed for medicines to treat COVID-19.
This includes a rapid early review of results, with early stopping rules, that limits the risk of extended exposure to inactive treatments.
The overall programme includes master protocols for interventions for prevention and treatment at different stages.
Lavange L et al. Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV): Designing Master Protocols for Evaluation of Candidate COVID-19 Therapeutics. Ann Int Med. DOI: 10.7326/M21-1269 (29 June 2021).