May 2003

Contents

Editorial

• Volume 4 Number 4 May 2003

Conference reports

• 4th International Workshop on Clinical Pharmacology of HIV Therapy, 27-29 March 2003, Cannes, France

• Can low NVP plasma concentrations explain the results seen in the EFV and NVP containing arms of the NARVAL study?

• Up to one third of patients receiving standard doses of NNRTIs may be being underdosed

• Nelfinavir concentrations are significantly higher in HIV/HCV co-infected patients with cirrhosis

• Less diarrhoea and bioequivalence with the new nelfinavir 625mg tablet

• The potential for probenecid to have a serious interaction with HIV-1 protease inhibitors

• PK studies reveal significant sex/gender differences

• Pregnancy-related PK studies

• New test to measure intracellular levels of nucleosides

• Case studies for therapeutic drug monitoring (TDM)

• Launch of guide to the use of drug level monitoring

• 10th Conference on Retroviruses and Opportunistic Infections (CROI), 10-14 February 2003, Boston, USA

• Pharmacokinetic papers from 10th CROI

• Pediatric studies from 10th CROI

Antiretrovirals

• T-20 access programme to continue in UK for a further two months

• Durability and success capability of HAART: 4.5 years follow-up

• Older HIV-positive patients in the era of HAART: changing of a scenario

• Immune reconstitution in older HIV-positive individuals

Treatment access

• The City turns up the heat on drug companies to make treatment available in poorest countries

• Lancet commentary concludes that prevention and treatment in South Africa are affordable and desirable

• South Africa treatment protests go global

• Gilead to sell tenofovir at cost to 68 countries

• New advocacy coalition demands emergency funding from rich governments for Global Fund

Lipodystrophy and metabolic complications

• Statins and fibrates both relatively effective for PI-induced hyperlipidemia

• Pioglitazone subjectively improves body shape abnormalities

Hepatitis coinfection

• BHIVA HIV/hepatitis B and HIV/hepatitis C co-infection guidelines (2003): posted to web for consultation

• Index of biochemical markers could reduce need for biopsy by half in HIV/HCV co-infected patients

• HCV protects against abnormal blood lipids in HAART-treated HIV patients

• HCV levels in semen

Basic science and immunology

• Tissue T-cell analysis represents renewed challenge to ‘tap and drain’ orthodoxy

Resistance

• Study reveals new reverse transcriptase mutations

Nutrition

• Integrating nutrition therapy into medical management of HIV: a supplement of Clinical Infectious Diseases

On the web

• 38th Annual Meeting of the European Association for the Study of the Liver (EASL)

• First European HIV Drug Resistance Workshop

• Further Coverage of 10th Retrovirus Conference

• Medscape articles

• Newsletters and journals: IAPAC Monthly, AIDS Treatment News, STEP Perspective, PRN Notebook, Hopkins HIV Report, GHMC Treatment Issues, TAG Line

• Nutritional Care Manual for HIV-positive people

PDFs

• Volume 4 Number 4 May 2003 PDF