11 June 2006

Contents

Conference reports

• 7th International Workshop on Clinical Pharmacology of HIV Therapy, 20-22 April 2006, Lisbon

• Efavirenz levels above recommended upper target in 20% of African patients in Senegal

• Lower dose of AZT provides adequate exposure in patients with low body weight

• Pharmacokinetics for generic fixed dose combinations for children are comparable to the branded products

• Caution against dividing adult FDCs (Triomune) for young children

• University of Liverpool audit of paediatric TDM

• Age-dependent pharmacokinetics of 3TC in children

• Use of small sample drug level monitoring for paediatric PI concentrations

• Intracellular and plasma measurements of AZT and 3TC and their metabolites in neonates

• Effect of pregnancy on PK of protease inhibitors

• Using enzyme inducers to reduce the half-life of nevirapine

• Relationship between nevirapine concentrations and virological failure in a clinical setting

• Summary of drug interaction studies