HTB homepage • Conference reports • Articles by subject • Subscribe September 2007 Contents Editorial Volume 8 Number 8/9 August/September 2007 Treatment alerts Update on nelfinavir recall: plan for safety registries Pfizer issue Dear Doctor letter over EMS content in US formulation of nelfinavir Conference reports 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention, 22-25 July 2007, Sydney HIV viraemia may explain increased risk of cardiovascular disease, death and other serious events in people interrupting treatment in the SMART trial: new study to randomise people with CD4 counts >500 to start immediate treatment or defer to <350 cells/mm3 CD4 increases in immunological non-responders despite suppressive therapy following switch to nuke-sparing regimen of ATZ/SQV/r Darunavir/r shows superiority over lopinavir/r at 48 weeks in TITAN trial Maraviroc fails to show non-inferiority to efavirenz in treatment-naive patients: 48 week results Importance of using maraviroc in combination with other active drugs in treatment-experienced patients Week 48 raltegravir results in treatment-naive phase II dose-finding study DUET studies clarify antiviral efficacy of etravirine and cross-resistance profile to other NNRTIs Boosting atazanavir in treatment-naive patients, and impact on lipids after switching from lopinavir/r Saquinavir/r vs lopinavir/r in treatment-naive patients Fosamprenavir/r vs atazanvir/r in treatment-naive patients Antiretroviral therapy initiated before 12 weeks of age reduces early mortality in young infants; interim results from the CHER study Very low transmission rates among breastfeeding women receiving ART Use of pre-exposure prophylaxis (PrEP) by sero-different couples wanting to conceive a child Increased incidence of miscarriage with efavirenz use No impact of HSV-2 suppressive therapy on HIV incidence Penile washing directly after sex increased the risk of acquiring HIV: circumcision effective for men in high prevalence populations no protective effect in gay men HBV or HCV coinfection produced higher risk from treatment interruptions: drug holidays and hepatitis dont mix 9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, 19-21 July 2007, Sydney Can nevirapine be safely substituted for other agents in those with high CD4 cell counts and virologic suppression? Do children with perinatally acquired HIV infection have problems with metabolism and body shape? The growth hormone releasing factor analogue tesamorelin (TH9507) reduces visceral fat, but what else does it do? Does diabetes have the same impact on cardiovascular risk in HIV-positive patients as it does in the general population? Can nucleoside RT inhibitors directly cause insulin resistance? Do dyslipidemia, insulin resistance, and body shape changes differ according to race or ethnicity? Is lipoatrophy associated with vascular dysfunction? Antiretrovirals Maraviroc approved in the US Monogram launches Trofile HIV co-receptor tropism test Treatment access Mbeki draws international scorn for firing deputy health minister Lesotho to revise national guidelines to include tenofovir first line International AIDS treatment advocacy group says overhaul needed to reach new G8 treatment goals Indian court ruling in Novartis case protects India as the pharmacy of the developing world Abbott drops lawsuit against community action Pregnancy UK (BHIVA) pregnancy guidelines online for comment (2007) Increased rates of pre-term delivery are associated with the Initiation of HAART during pregnancy: a single-centre cohort study Paediatric care First paediatric fixed dose triple combination (Pedimune) is approved by FDA for use in PEPFAR Caution in dosing paediatric oral solution of Kaletra Paediatric formulation of fosamprenavir approved in the US Deferred treatment arm of CHER study stopped Hepatitis coinfection BMS issue Dear Doctor letter about risk of entecavir in HIV/HBV coinfection Other news The dispersal process for HIV positive asylum seekers PDFs Volume 8 Number 8/9 August/September 2007 PDF HTB homepage • Conference reports • Articles by subject • Subscribe
