30 December 2009

Contents

Treatment alerts

• Tibotec issues Dear Doctor letter in Europe concerning severe etravirine reactions: three case reports

Conference reports

• 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention, 19-23 July 2009, Cape Town

• Early infant diagnosis

• Difficulties with implementation

• Infant outcomes

• Improved neurodevelopmental outcomes

• Treating children exposed to single dose nevirapine for PMTCT

• Using a nevirapine-containing fixed dose combination in the CHAPAS trial

• Once a day lamivudine and abacavir, and abacavir hypersensitivity in the ARROW trial

Antiretrovirals

• GSK and Pfizer launch joint HIV collaboration

Treatment access

• AIDS and mortality in South Africa

• Punishing success in tackling AIDS: funders retreat could wipe out health gains in HIV affected countries

• FDA approval of generic ARVs

PK and drug interactions

• Reduced etravirine levels after direct switch from efavirenz

• Gemfibrozil significantly reduced by lopinavir/r

Resistance

• Rate of accumulation of TAMS slow in patients continuing on failing AZT or d4T containing regimens