December 2014

Contents

Editorial

• November-December 2014: Volume 15 Number 11/12

Treatment alerts

• ARV supply issues cause treatment interruptions in a UK clinic

Conference reports

• 12th Glasgow Congress on HIV Therapy, 2-6 November 2014, Glasgow

• Savings to the NHS predicted from switching to generic antiretrovirals

• Lower dose efavirenz effective in two studies

• Should tenofovir dose be 200 – 250 mg when used with protease inhibitors?

• 3TC inferior to FTC in Dutch cohort but interchangeable in other studies

• Suicide not associated with efavirenz use in the D:A:D cohort study

• Gender differences in use of cardiovascular disease-related interventions: D:A:D study

• Efavirenz decreases exposure to hormonal contraceptive implant

• Increased risk of ART-related hepatotoxicity in HIV positive pregnant women

• Darunavir pharmacokinetics in pregnancy and postpartum

• BHIVA Autumn Conference, 9-10 October 2014, London

• Good management of HIV positive pregnant women in UK – with some room for improvement

• Southern African Clinicians Society Conference, 24-27 September 2014, Cape Town, South Africa

• Efavirenz-associated gynaecomastia reported to the national HIV and TB healthcare workers hotline in South Africa

• Infants start ART too late but improvement over time in Southern Africa

• Treatment outcomes in HIV positive and negative people with drug resistant TB in Khayelitsha, Cape Town

• Pregnancy a risk factor for poor antiretroviral treatment outcomes in South African adolescents

Antiretrovirals

• Equivalent efficacy with lower dose darunavir

Side effects

• Poppers-related maculopathy linked to permanent and serious vision loss

Hepatitis coinfection

• US activists called on Gilead to set a per-treatment price for sofosbuvir/ledipasvir

HIV prevention and transmission

• UK PROUD study to provide PrEP to all participants earlier than expected: planned follow-up to continue to two years

• IPERGAY PrEP study shows early efficacy in protecting gay men from HIV: all participants to switch to active drug

• HIV in the UK 2014: Public Health England report on incidence and care

Cure research

• Three papers on macrophages and HIV infection

On the web

• Conferences

• Online article

PDFs

• November/December 2014: Volume 15 Number 11/12