Q and A


Will changing the time I took meds cause fever and nightmares?

I changed the time of taking the pill and now I am sick. my body is painful, I have flu,   nightmares, and I am sweating at night. Is my CD4 count dropping?


Hi there

I really need more details about which meds you are taking and what time changes you made.

If your meds include a drug called efavirenz, then these symptoms could all be side effects from changing the time.

For example, efavirenz needs to be taken before you go to sleep and not after a heavy meal, otherwise the side effects will be worse.

Most people find it impossible to take efavirenz during the day. Taking it after a high fat meal increases the dose and also makes side effects worse – especially getting nightmares.

Also, you might just be unlucly and actually have the flu – and that this is a coincidence.

If you didn’t have problems before, changing back to the original time is a good way to see if things get better. Please also contact your doctor who can look at other causes.


  1. Roy Trevelion

    Hi Lerato,
    It’s a good idea to take Trivenz before bedtime, on an empty stomach (or not with a high fat meal). Because being unable to sleep and having nightmares can be a side effect of Trivenz. Taking it this way can reduce these side effects. You can read more about this here.
    And you can read more about sleep disturbance in this guide to side effects and quality of life. You can talk to your doctor about whether your insomnia might be related to other things, not just Trivenz, such as stress and worry.

  2. Lerato

    Have been on Trivens for almost 11 months. thouggt I have had my fare share of its side effects but suddenly this week I am unable to sleep and just had a nightmare, get hungry in the middle of the night

  3. Lisa Thorley

    Hi Ngoza,

    Please talk to your doctor about this. This may or may not be related to the medication, though its unlikely that it is.

  4. Ngoza

    Viraday makes my legs freeze like I have frostbite. I can hardly walk for the past year. What can I do

  5. Lisa Thorley

    Hi Mike,

    Trivenz is a generic version of Atripla, it contains the following compounds: efavirenz + tenofovir DF + FTC. Though Efavirenz can included in Trivenz they also come in a single tablet form, and one which includes just the Efavirenz. Please see here for more info:


  6. Mike

    Is there any difference between trivenz and Efavirenz medication am confused

  7. Simon Collins

    Hi Dorothy, Odimune can have all these side effects, but they normally get easier after the first week or two. This link has more detailed information about efavirenz side effects and things that can help. Efavirenz is the active drug in Odimune causing these.

  8. Dorothy

    Hi, I just started with my arv treatment last night and i was given edimunne the same night i had hot flashes, nightmares and i started vomitting. Is it normal to have such side effect and how long will they occur?


Your email address will not be published. Required fields are marked *