Can dolutegravir cause anxiety?
I will have some questions, only seeking adequate opinions,
I am a 22 y/o and my doctors cannot clearly find the answers. After some period of classic pre-hiv diagnosis I got my positive test at the 5th month of infectionwith nearly 14,000,000 VL and 500 CD4.
On the 6th month I commenced treatment with CD4 962, CD4:CD8 1:1.After five months on abc/3tc+dolutegravir my VL is 34 and CD4 1600, CD4:CD8 1:1.
My immune profile is quite fantastic I believe, but since the beginning of my treatment respectively between days 5 and 15 I started to have a wide range of neuro-psychotic symptoms like heavy breathing, anxiety, heart palpitations, depressiveness, malaise, memory worsening, blood pressure fluctuations and other difficult to explain conditions.
A very broad range of blood and organ screening was done proving that my vitamin profile, lipid profile, cardiovascular, hepatic, renal, endocrine levels and morphology are are all right, including blood saturation etc. However, one of my doctors denies that it might be the medication causing this bit rather a neurodegenerative condition if not a cardiovascular/artherial.
To me this is quite unnecessary, knowing my scientifically very early reaction to the infection and successful treatment started as early as possible (6th month after infection) and the absence of the symptoms before treatment. I’d love to know your opinions and views as well as experience in similar cases.
Thank you in advance.
Thanks for your comment – and for letting us post the answer online.
Neuropsychiatric side effects are a well-reported side-effect of dolutegravir – so it is definitely worth doing back to your doctor.
Please see the info here:
Also the links to more detailed information in the product information (especially Table 3 in section 4.8.
This lists insomnia, depression and anxiety as common psychiatric side effects which means they can affect up to 1 in 10 people (10%).
At i-Base we got lots of questions about this very soon after dolutegravir was approved, Anecdotally, most people switch to an alternative HIV drug and the symptoms resolve.