Question
Can TLD be used as PEP?
5 January 2022. Related: All topics, HIV transmission, PEP/PEPSE.
Can TLD help someone who has been in contact with an HIV positive person to prevent them from contracting HIV before 72 hrs?
Answer
Hi, how are you?
Yes you can. TLD is a combination that can be used as PEP and for the management of active HIV infection. PEP stands for post exposure prophylaxis. PEP is used to prevent established infection after exposure.
TLD is a first choice recommendation for PEP. The course lasts 28 days following a high risk exposure. It is only used in cases where the exposure was within 72 hours. After this, regardless of what drug is prescribed, PEP will not work.
However, if your partner was using effective HIV treatment (ART) , you will not be at risk. Having an undetectable viral load on ART means HIV is not a risk. Please see:
i-base.info/u-equals-u/
If you have any more questions please ask,
Josh.
Hi, may I ask regarding TLD as PEP.. where can I read the study about TLD as PEP? Thank you!
Hi Adnan, what is the name of the PEP you are taking? Different PEP combinations will cause different effects. How long have you been feeling sleepy/fatigued? and at what time in the day do you begin to feel like this?
As you are on PEP it is very unlikely that this is a symptom of HIV. It would also be expected that you would be experiencing a number of symptoms, not just one. Fatigue/tiredness is very non-specific. It is possible that it is a side effect of PEP, or it could be caused by stress. Is there anything going on your life (apart from being on PEP) that could be causing you more stress than normal?
Hi, Im using PEP – TLD after 19hours of possible exposure and it is the 10th day. I consume it every 11.30 am. Sometimes after work I just feel little bit sleepy, but not like tiredness or fatigue. Is it a side effect of TLD? and how to differ fatigue as HIV symptom and as a normal body reaction?
thank you
Hi Tina
Thanks.
Please see this factsheet on PEP that answers all your Qs:
https://i-base.info/qa/factsheets/pep-faq
I had exposure with someone hiv positive at about 10:30hrs. I contacted a doctor and was given a blue tablet as a start dose of my PEP. I didn’t ask the name of the blue tablet. The doctor felt if I can’t get my prescription of PEP in time I will be covered by that start dose/blue tablet. I took the blue tablet at about 3 pm. I then went to the pharmacy and managed to get a 30 day supply of ACRIPTEGA for my PEP. When I got home at 17:30 I decided to take another dose of the ACRIPTEGA. AM I AT RISK OF ANYTHING?
Hi Hong, no you do not need to extend the course of PEP. As you are on established treatment, PEP will act as PrEP for the duration of the course. There is no risk from further exposures while you are taking it. You can finish PEP when originally planned.
Hi Jose, I am currently on PEP (TLD) but I have second exposure on my 21th day of PEP. Do I need to extend my Pep course or TLD already worked as Prep.
Thank you.
Hi Jitendra, using a condom means there will be no risk of transmission. You can have sex while on PEP using a condom.
After PEP you can test 6 weeks after the last dose. This will be with a 4th generation antigen/antibody test. The result will be conclusive.
Can I do protected sex (with condoms) with wife during pep . Is that any chances of spreading HIV TO PARTNER
AND AS IAM ON PEP AFTER HOW MUCH TIME I WILL GO FOR TEST AND FOR WHICH TEST . AND SUPPOSE IF THE REPORT NEGATIVE THAN CAN I GO FOR OTHER TEST
Hi Jitendra, DLT and TLD are the same thing. TLD stands for dolutegravir, lamviduine and tenofovir. The order of T L D does not change the ingredients that are in the drug. DLT is suitable to be used as PEP. As you started PEP within 72 hours this means that PEP will be effective and mean your risk of HIV is low. Being on PEP for a month does not lead to any major side effects.