Q and A

Question

Can marijuana interact with PEP?

29 June 2022. Related: All topics, Drug interactions, PEP/PEPSE.

I am currently taking dolutegravir/lamivudine/tenofovir as PEP and I wanted to check if it has any interactions with marijuana?

I can’t seem to find anything online so I wanted to know if smoking marijuana while taking it will impact the effectiveness of the PEP.

Answer

Answer: Josh Peasegood

Hi, how are you doing?

There is no interaction between your combination of PEP and marijuana.

Your course of PEP will remain as effective as it would be if you did not smoke marijuana.

Please see this link for more information about PEP:
https://i-base.info/qa/factsheets/pep-faq

Josh.

10 comments

  1. Simon Collins •

    Hi David, marijuana does not interact with any HIV meds.

  2. David •

    I will be taking emtricitabine-tenofovir (TDF) 200-300 mg tablet can I still smoke marijuana

  3. Josh Peasegood •

    Hi K, yes you are to smoke weed while you are taking PEP. There is no risk of an interaction between the two.

  4. K •

    I’ll be taking pep 2 pills (emtricitabine-tenofovir disoproxil fumarate oral 200 mg-300 mg) and (Tivicay) will I still be able to smoke weed without it interacting?

  5. Josh Peasegood •

    Hi Thomas, Kratom and cannabis will not interact with PEP. There is no risk of these two substances reducing the effectiveness of PEP. It is safe to take them together.

    More information about PEP can be found here: https://i-base.info/qa/factsheets/pep-faq

  6. Thomas •

    Hello,
    I am on PEP Kocitaf and have been taking it everyday consistently. On days 10, 14,15,16 I drank kratom around the same time that I take my PEP meds and was wondering if it will affect the effectiveness of the PEP drug. I also smoke cannabis every night which is around the same time I take the PEP as well.

  7. Josh Peasegood •

    Hi Janette, is this question in respect to HIV?

  8. Janette •

    Can you take cannibis and Pantoprasool together and what are the effects on cancer?

  9. Josh Peasegood •

    Hi Jason, what medication did you use for PEP? If it was TLD (https://i-base.info/guides/14970) there is no interaction between PEP and albendazole. They will not effect how well the other works.

  10. Jason •

    I took albendazole 400mg one time syrup while on pep, will there be an interaction there? Will it affect one or the other and make it ineffective?