Q and A


I have taken calcium supplements with TLD…

I am new to dolutegravir. I took my TLD at 8am, then drank my whey protein supplement at 10:15 am. Did this for 2 straight days without realising that my whey protein contains 130mg of calcium. Will this affect my treatment?


Hi, how are you doing?

Calcium can reduce how much dolutegravir is absorbed by the body. As this was for only 2 days, it is won’t have allowed your viral load to rebound. The other 2 drugs in TLD will not be affected and some dolutegravir will still be effective.

With calcium containing supplements it is recommended to take it 2 hours before or 6 hours after your treatment e.g., 6am or 2pm. Usually it is easier to take the supplement at the opposite end of the day to when you take your treatment. This is the best way to avoid interaction.



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