Question
I switched Truvada and Isentress…
26 May 2023. Related: Adherence, All topics, PEP/PEPSE.
I am taking PEP (Truvada and Isentress) and about 6-7 days into my treatment I accidentally switched the caps on my bottles. I took Truvada twice per day and Isentress once daily for approximately 3-4 days. I realised this mistake and changed back. Is there anything else I can do? Am I at increased risk now?
Answer
Hi, how are you doing?
No. You are not at an increased risk.
Truvada alone is enough to be used as PEP.
Adding Isentress is used to provide a more robust regiment, but the evidence for this is limited. It is suitable to use Truvada alone as PEP.
This means that for the days you were taking a lower dose of Isentress, you were still taking PEP. You have not reduced how effective it will be and you do not need to do anything more.
Josh.
Hi Peet, yes this is a good suggestion and it is good that your doctor is being proactive.
Ranega is a newer combination which is one pill a day as mentioned. More people find it also has fewer side effects.
Is there anything specific that you are uncertain about regarding the switch?
Information about Ranega (TLD) can be found here:
https://i-base.info/guides/14970
Good day.
I’m 75…31 years positive with no problems. My new doctor suggests I change from Isentress/Truvada to Ragena which is only one tablet a day…only to make it easier not to take a second isentress per day. He did explain that the one combination pill has just newer version of isentress in it…otherwise it’s the same combination.
Is that a good suggestion…I haven’t done it yet, is a bit uncertain.
Hi Maria, no you do not need to be worried. As you had been taking PEP while you had this second exposure you would be protected from further exposures. You were not required to extend your course of PEP. Finishing on day 28 would have been suitable.
Volutrip and Reydin are the same medication. They have different names because they have been made by different manufacturers. They will still work in the same way.
I had an exposure on 20 July 2023 and started taking VOLUTRIP( pep)from clinic on 21 July .Accidentally I had another exposure on 8 August 2023 with another guy I continued taking volutrip then I finished on day 28…I was very worried I went to the pharmacy to buy volutrip which is R400 then I didn’t have enough money, the pharmacist decided to give me Redyin to take them for 15 days….should I be worried please help me Sir