Q and A

Question

Does having a high viral load at the start lead to a poor prognosis?

I was diagnosed positive as a result of blood tests during a period of severe illness, v high fevers, various inflammations etc. This occurred within three weeks of actual infection, as the likely event was identifiable.
Viral load was in excess of log7 (too high for the equipment to put a figure on it), CD4 was around 550.
Eight months later on ART the viral load was down to 75 and CD 660.

My question is does this very high VL and the severe primary infection symptoms have any future implications? The clinic staff seem to think not

Answer

Hi, how are you doing?

A viral load of Log7 suggests a viral load greater than 1000000. A viral load this high often means recent infection.

It is great to hear how well you have responded to treatment.

You now have a viral load considered undetectable (anything below 200) and your CD4 count has remained within a healthy range (430-1690).

The initial high viral load is not prognostic of the progression of HIV. Your clinical staff are correct in that this does not impact how HIV is affecting you.

You have responded well to treatment and this is the biggest factor which determines the course of HIV. As you have both results within healthy ranges, the impact of HIV on your health is now minimal, if at all. There are no specific implications you need to be worried about because of the initial high viral load.

Josh.

2 comments

  1. Josh Peasegood

    Hi TTRO, what you have described is not a risk for HIV. You had no reason to start PEP given that this is low to zero risk of transmission.

    Please see here for more information about testing and transmission: https://i-base.info/qa/factsheets/hiv-transmission-and-testing

  2. TTRO

    Hi, I had protected (Condom) sex with sex worker, but while removing condom it might touch to my penis. My penis has small white pimple from childhood and I am no circumsation. So I took pep within twenty four hour( tenofivir 25 mg, emtricitabine 200mg, Dolutegravir 50 mg in one pill) one pill everyday on exact same time for 29 days.

    While on pep I had little pain in my neck when I move my neck. Sonography in neck suggest no issues.

    After finishing pep, I had rahses on my solder after 4 th day post pep. It lasted for 1 week. It is still there but now not that much visible. When it came it was itchy but after that it is not itchy.

    I have pain in neck when I move my neck, pain in armpit when I squeeze my hand togather.

    I had little diarrhea for one day.

    I had screening test at start of pep p24 antigen antibody was negative.

    I had pcr rna and p24 test on 22nd day of pep both came negative.

    I had pcr rna and pro viral dna test post pep 12th day which came negative.

    Am I infected?

    What are the chances of my next test turn positive?

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