April 2010

Contents

Editorial

• Volume 11 Number 3/4 March/April 2010

Special reports

• CROI 2010: non technical summary of 12 key areas of research

Conference reports

• 17th Conference on Retroviruses and Opportunistic Infections (CROI), 16-19 February 2010, San Francisco

• Treatment reduces infections by over 90%: a theme that is here to stay

• ACTG 5205: atazanavir/ritonavir vs efavirenz in treatment naive patients

• Pipeline compounds and new approaches to treatment

• Clinical benefits of stopping smoking: CVD and CHD risk returns to that of ‘previous smoker’ in HIV-positive people within three years

• HIV increases the risk of lung cancer, independent of smoking status

• HIV positive people in the HOPS cohort have 4-fold risk of fracture compared to general population in the US

• Vitamin D deficiencies in HIV management

• OCTANE 2: nevirapine and lopinavir/r are similar when used with tenofovir and FTC in treatment-naive women

• HIV incidence and retesting in pregnancy

• Efavirenz use in pregnancy and birth outcomes

• Pregnancy outcomes in women using non-AZT HAART in Europe

• When should HAART be initiated in pregnancy to achieve an undetectable viral load?

• Pregnancy outcomes in infants exposed to maternal antiretrovirals in utero

• Maternal TB, HIV and pregnancy

Antiretrovirals

• Non-refrigerated ritonavir tablet approved in Europe and the US

• FDA safety review of saquinavir (Invirase) and possible association with abnormal heart rhythms

• FDA updates US label for darunavir (Prezista)

• FDA safety announcement about ddI and non-cirrhotic portal hypertension

• FDA label change for lopinavir/r (Kaletra)

• FDA notice about drug interactions with etravirine (Intelence)

Treatment access

• FDA approval of generic ARVs

• Waiting lists grow in the US

• South African antiretroviral treatment guidelines (2010)

• Tenofovir registered in Russia

• MSF criticise Abbott over new ritonavir formulation

Pregnancy

• Infant feeding in the UK (2010): draft guidelines online for comment

Guidelines

• BHIVA draft guidelines for the treatment of opportunistic infections (2010): online for comment

• Legal issues on HIV transmission and the law for healthcare workers: draft guidelines online for comment

Basic science and immunology

• Early predictors of disease progression

• Sex and the single microbicide

• Baseline naive CD4 T cell numbers predict the immunological response to ART

• Has poor CD4 T cell reconstitution in the gut been exaggerated?

On the web

• Journal articles

PDFs

• Volume 11 Number 3/4 March/April2010 PDF

• CROI 2010: non-technical summary of 12 key areas of research PDF