January 2015

Contents

Editorial

• January/February 2015: Volume 16 Number 1/2

Conference reports

• Five Nations Conference on HIV and Hepatitis – 8-9 December 2014, London

• Summary of the pre-conference clinical course

• Hepatitis C drug access: Europe is the new Africa

• 45th Union World Conference on Lung Health, 28 October – 1 November 2014, Barcelona, Spain

• Good outcomes within the National Bedaquiline Clinical Access programme in South Africa

• Pharmacokinetics and safety of moxifloxacin in children

• TB in the ARROW trial of children on ART

• Problems giving current second line TB drugs to children

Antiretrovirals

• Dolutegravir and Truimeq approved in England

• London prescribing guidelines updated to include dolutegravir and Triumeq

• Adequate cerebrospinal fluid exposure of efavirenz when dosed at 400 mg

Treatment access

• Morocco’s acceptance of EU patent law threatens millions of lives

• Global Fund releases end-2104 numbers

• India rejects Gilead’s patent application for sofosbuvir

Pregnancy

• Three drug regimen superior for preventing vertical transmission in the PROMISE study

Side effects

• CMV associated with 50% increased risk of non-AIDS related mortality in HIV positive people

• Impact of smoking on life expectancy in HIV infection

Hepatitis coinfection

• Hepatitis C combination from AbbVie licensed in the UK: ombitasvir/paritaprevir/ritonavir (Viekirax) and dasabuvir (Exviera)

HIV prevention and transmission

• HIV prevention budget for 2015 slashed by 50%, then rapidly reinstated

• Grassroots demand grows for early access to PrEP in the UK

• New York announces new policy to dramatically reduce HIV incidence by 2020

Basic science and immunology

• Is HIV weakening over time? Unlikely, and a sense of déjà vu…

• Quantification of latent HIV induction by vorinostat

On the web

• Online video resource – Aidspans video on gay life and death in Ghana

• Online article – Journal of Virus Eradication: New open-access journal

• Community report – RITA: HIV and kidney disease

PDFs

• January/February 2015: Volume 16 Number 1/2