HTB homepage • Conference reports • Articles by subject • Subscribe February 2017 Contents Editorial January/February 2017: Volume 18 Number 1/2 Supplements Pocket guides: A7 concertina leaflets Conference reports 24th Conference on Retroviruses and Opportunistic Infections (CROI 2017), 13-16 February 2017, Seattle Pharmacokinetics and full phase 2 results for bictegravir, a new integrase inhibitor New NNRTI doravirine is non-inferior to darunavir/r in phase 3 treatment naive study NRTI GS-9131 resurfaces at CROI 2017: in vitro sensitivity to nuke-resistant HIV Dolutegravir exposure increases when fixed dose combination tablets are crushed Pharmacokinetics, safety and efficacy of dolutegravir in very young children Efavirenz, tenofovir and emtricitabine associated with fewest adverse birth outcomes in Botswana Adverse pregnancy outcomes and risk factors in the PROMISE trial Women on lopinavir/ritonavir-based regimens at conception at higher risk of preterm delivery in UK study No increase in adverse birth outcomes with maternal TDF/FTC in US study Dolutegravir monotherapy studies halted due to integrase resistance: dual therapy studies continue No evidence of accelerated brain ageing in HIV positive people on effective ART Acute infection with wild-type HIV on PrEP with good drug levels Fit for purpose: antiretroviral treatment optimisation Feb 2017 Seattle-lite: pre-conference workshops – watch online Antiretrovirals US Stribild label updated: new indication to include patients age 12 and older Option to take crushed Stribild tablets with food or enteral nutrition ART adherence in first four months predicts long-term viral suppression in 12-year study Effects of ART initiation on human papillomavirus antibody response Treatment access Sutezolid added to MPP as potential TB drug AT LAST: Gay men and transgender people in England get vaccine to prevent genital warts and anal cancer – impressive pilot results Pregnancy Pregnancy common in ART trials in sub-Saharan Africa despite exclusion criteria Guidelines Drug-drug interactions and hormone therapy for gender transitioning New NICE/PHE testing guidelines (2017) WHO guidelines on HIV self-testing and partner notification (2017) Coinfections and complications Rosuvastatin for chronic obstructive pulmonary disease (COPD) in people with HIV HIV prevention and transmission Brighton heads towards zero HIV: first UK city with UN Fast Track status Four London clinics report dramatic drops in HIV incidence in gay men: PrEP, early testing and early ART likely to be key NHS England fudges PrEP access and delays on-demand access to PrEP by years; blocks doctors from prescribing PrEP now Update on PrEP in Scotland New York reports fewer HIV diagnoses in 2015: target to reduce new infections by 75% by 2020 Basic science and immunology Soluble CD163 as a marker of CMV mediated immune activation Levels of CMV antibody are linked to HIV progression and immune activation in Ugandan women PDFs January/February 2017: Volume 18 Number 1/2 HTB homepage • Conference reports • Articles by subject • Subscribe
