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2018
June
29
HTB
29 June 2018
Contents
Editorial
29 June 2018: vol 19 no 11: darunavir/cobicistat alert and PK reports
Treatment alerts
New contraindication against using darunavir/cobicistat during pregnancy
Janssen Dear Doctor letter: Prezista (darunavir), Rezolsta ▼(darunavir/cobicistat)and Symtuza ▼(darunavir/cobicistat/emtricitabine/tenofovir alafenamide)
Conference reports
19th International Workshop on Clinical Pharmacology, 22–24 May 2018, Baltimore
Unbound dolutegravir plasma concentrations unchanged in pregnancy and standard dosing crosses the placenta in placental perfusion model
Etravirine dispersible paediatric tablet has greater bioavailability when dispersed in water compared to swallowed whole
Reduced exposure to elvitegravir in pregnancy: results from the PANNA Network
Rifabutin dosed 2.5 mg/kg daily with lopinavir/r in children achieves comparable exposure to adults
No clinically relevant reduction in oral cabotegravir when co-administered with rifabutin
Boosted darunavir 800/100 mg twice daily might overcome interaction with rifampicin
Efavirenz side effects and other drug-drug interactions are common in Ugandan cohort
Antiretrovirals
China approves albuvirtide: a once-weekly injectable entry inhibitor
Single dose PRO140 mAb reduces viral load by 0.5 log copies/mL in people with multidrug resistance
Coinfections and complications
RITA: issue on lung health
HIV prevention and transmission
New FDA guidance for developing PrEP drugs
UK PrEP IMPACT trial announces 3000 new places for gay men but low uptake by women, African and transgender people
Cure research
Cure research: open access publications
On the web
US community call for coalition for long-term survivors
PDFs
29 June 2018: vol 19 no 11
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Early access
In-utero tenofovir-based PrEP has no effect on children’s bone mineral density
25 September 2023
>10% weight gain during first two years of ART linked to double the risk of cardiometabolic disease
25 September 2023
Mutations associated with resistance to dapivirine vaginal ring: reported in 7/38 women seroconverting in the open-label HOPE study
25 September 2023
Early phase 1 HIV vaccine study launched in the US and South Africa
21 September 2023
All early access reports
Current issues
September 2023
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Special report
Latest statistics on HIV in the UK: data for 2021
1 December 2022
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