Q and A


Is there anything after second line treatment?

What happens if second line treatment fails?


Thanks for getting in touch,

If you’ve had resistance to two lines of treatment, this doesn’t mean that there aren’t other options available. What you’re offered will depend on where you live and what you’ve been resistant to. The following discusses what the World Health Organisation recommend when there has been treatment failure:


You may also find the following guide helpful:



  1. Roy Trevelion

    Hi Kimberly,

    I’m sorry to hear about your weight loss. But do you mean tenofovir, efavirenz and emtricitabine? How long have you been taking it?

    Please see this Q&A. It says fat loss (from the face, arms, legs and buttocks) is a common side effect from using combinations that include either d4T (also called stavudine or Zerit) or AZT (also called zidovudine or Retrovir). But these are not widely used now.

    Did you take d4T or AZT before? You can ask your doctor about it. Here’s the guide to fat loss. There’s a lot to read here, but please talk to your doctor and find out what can be done.

  2. Kimberly

    Hi I am losing weight in my face , butt and thighs, I feel very uncomfortable with myself, I am presently taking tenofovir, efavirenz and distributable


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