HIV i-Base

PrEP, PEP and PEPSE

This page includes links to information about PrEP, PEP and PEPSE.

PrEP = Pre Exposure Prophylaxis.

HIV testing guideIt is the term for using HIV drugs before exposure to reduce the chance of getting HIV. This is usually daily by someone who is HIV negative, to reduce their chance of catching HIV. PrEP uses two HIV drugs (tenofovir and FTC) in one pill (called Truvada) before (and after) exposure.

PEP = Post Exposure Prophylaxis.

It is the term for using HIV drugs after an exposure to reduce the chance of an infection.

PEPSE = PEP after Sexual Exposure

This is for example if you didn’t use a condom or if the condom broke or came off. It is used to separate this from PEP used after occupational exposure – for example when a health worker is scratched by a needle or syringe.

Questions to i-Base about PEP and/or PrEP

The i-Base Q&A service has been asked many questions about PEP.

These are links to some of the questions answered online.

Links to more information and resources

i-Base guide to HIV transmission and testing

PEP, PEPSE and PrEP section

Articles from i-Base on reducing HIV transmission

Activists call for urgency of NHS access to PrEP (June 2015)

PrEP reduced HIV risk by at least 86% in PROUD: no transmissions likely from people taking meds. (March 2015)

“On demand” PrEP dosing in IPERGAY: 86% reduced risk of HIV, no transmissions with active drug use. (March 2015)

Other HIV PrEP studies at CROI 2015: implementation of oral PrEP and problems with tenofovir gel. (March 2015)

No HIV transmissions between gay couples when viral load is undetectable: preliminary results from “Opposites Attract” study in Australia, Thailand and Brazil. (March 2015)

Q&A on PrEP in the UK and changes to the HIV PROUD study. (October 2014)

UK PROUD study to provide PrEP earlier than expected: planned follow-up in this HIV prevention study to continue for two years. (16 October 2014).

IPERGAY PrEP study shows early efficacy in protecting gay men from HIV: all participants to switch to active drug (October 2014)

US PrEP guidelines: emphasis on broad access may miss optimal use by people at highest risk (May 2014)

The little blue pill that can stop HIV: UK PROUD study (December 2013)

Oral PrEP acceptable to at least 50% of HIV negative gay men – May 2012

CROI 2012: PK modeling of daily TDF/FTC (Truvada) provides close to 100% protection against HIV infection – April 2012

HPA recommends universal HIV testing in the high incidence regions of the UK – December 2011

PrEP study (VOICE) stops use of tenofovir vaginal gel due to lack of efficacy – November 2011

DSMB stops oral tenofovir in VOICE PrEP study: no difference to placebo – September 2011

Treatment is prevention: ARV treatment reduces transmission by at least 96% – August 2011

TDF2 study: Daily oral PrEP reduces heterosexual HIV rates by 63% – August 2011

Tenofovir/FTC vs tenofovir as daily oral PrEP: Partners PrEP study – August 2011

Online presentations on treatment as prevention – August 2011

FEM-PrEP stops daily Truvada: similar infection rates as placebo – April 2011

CROI 2011: ARV prevention: oral PrEP, gels and treatment studies – March 2011

More results from the iPrEx study: daily Truvada protects high risk gay men – March 2011

Topical gels as PEP and PrEP: animal and human studies – March 2011

US CDC issue preliminary guidance for use of PrEP – February 2001

PrEP reduces transmission in gay men at high risk: iPrEx study – December 2010

Links to other websites

Information on THT website about PEP in the UK

Problems getting PEP (THT)

UK guidelines on PEP (BASHH 2006) PDF file

Patient information sheet (BASHH 2006) PDF file

Letter from Chief Medical Officer to ensure PEP is available in all UK hospitals

This important edition of Research Initiative, Treatment Action (RITA!) interviews key researchers and features two comprehensive reviews of preexposure prophylaxis (PrEP).

Research Initiative, Treatment Action (RITA!) – PrEP issue (winter 2013): interviews with key researchers and two comprehensive data reviews (PDF)