This page includes links to information about PrEP, PEP and PEPSE.
PrEP = Pre Exposure Prophylaxis.
It is the term for using HIV drugs before exposure to reduce the chance of getting HIV. This is usually daily by someone who is HIV negative, to reduce their chance of catching HIV. PrEP uses two HIV drugs (tenofovir and FTC) in one pill (called Truvada) before (and after) exposure.
PEP = Post Exposure Prophylaxis.
It is the term for using HIV drugs after an exposure to reduce the chance of an infection.
PEPSE = PEP after Sexual Exposure
This is for example if you didn’t use a condom or if the condom broke or came off. It is used to separate this from PEP used after occupational exposure – for example when a health worker is scratched by a needle or syringe.
Questions to i-Base about PEP and/or PrEP
The i-Base Q&A service has been asked many questions about PEP.
These are links to some of the questions answered online.
- How do I safely use PreP if I buy it online?
- What is PEP? (Post Exposure Prophylaxis)
- I have started PEP and what to know if I will be okay?
- Does PEP have side effects?
- Does PEP extend the window period for testing?
- Other online questions
Links to more information and resources
i-Base guide to HIV transmission and testing
Articles from i-Base on reducing HIV transmission
Activists call for urgency of NHS access to PrEP (June 2015)
Q&A on PrEP in the UK and changes to the HIV PROUD study. (October 2014)
The little blue pill that can stop HIV: UK PROUD study (December 2013)
Online presentations on treatment as prevention – August 2011
US CDC issue preliminary guidance for use of PrEP – February 2001
PrEP reduces transmission in gay men at high risk: iPrEx study – December 2010
Links to other websites
UK guidelines on PEP (BASHH 2006) PDF file
This important edition of Research Initiative, Treatment Action (RITA!) interviews key researchers and features two comprehensive reviews of preexposure prophylaxis (PrEP).