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Can hydroxychloroquine decrease immune activation in asymptomatic patients? This study is now closed and results presented at the IAS conference in Rome in July 2011 showed that HCQ had no benefit and actually produced a slight drop in CD4 count. …

This is a great question and the answer would be very important. But currently there is worryingly very little evidence to quantify the risk. A study called PARTNER is looking for sero-different couples (where one partner is HIV-negative and the …

The i-Base Q&A information service answered over 2000 questions last year. This one looks at research about HIV and cocaine use. Cocaine is widely used. In small amounts most people are lucky and are likely to have limited long-term affects. …

The changes to ARV prescribing in London were first reported in detail by i-Base here in April. We are now hearing from people where the new guidelines are not being followed. This includes cases of people having medications switched without a …

This edition of HTB might be appropriately tagged The Conference Issue as it includes reports from five meetings covering a wide range of treatment issues. We lead with a report from a workshop held in South Africa in March, that …

We are looking people who are dynamic, treatment literate and self motivated, who are happy to work independently and also as part of a team. There will be opportunities to develop new projects within the organisation. The successful candidates are …

An international workshop on nanomedicine for infectious diseases related to poverty was held in Magaliesberg, South Africa from 27–31 March 2011 and attended by about 70 delegates from 20 countries. This report includes an introduction to nanotechnology with examples for …

HIV Tedavi Bülteni Türkiye (HTB Turkey) is a Turkish-language publication produced by an independent group of Turkish doctors, activists and health care workers. The second edition is now available. HTB Türkiye.2 Nisan 2011 PDF (2.6MB) 2nd edition – April 2011 …

The March/April issue of HTB is now online. This issue leads with reports from the 18th Conference on Retroviruses and Opportunistic Infections (CROI). We also cover the proposed guidelines issued by the London HIV Consortium on prescribing antiretroviral treatment in …

Guidelines for London prescribing of antiretroviral drugs in 2011 The London HIV Consortium, the pan-London commissioning group for HIV services, has just outlined the results of the tender process for purchasing HIV drugs for the next two years. This is …

Guide to clinical trials (Russian) Клинические исследования: учебное пособие для активистов PDF (640 Kb)

HTB survey 2011 This year we are asking readers to help us by completing a short online survey about the publication HIV Treatment Bulletin and about i-Base in general. http://www.surveymonkey.com/s/8QQLN6X Your feedback is really important to us. Please take a …

Wednesday 30 March 2011 6–8pm After the success of the last treatment training session with Dr Tristan Barber,  i-Base are organising another question and answer workshop. This will include an update from the research presented at the CROI conference last …

Bite size news from CROI today includes links to interesting studies on new drugs in development. This includes: an integrase inhibitor that works against raltegravir resistance a new oral entry inhibitor a formulation of tenofovir in early development first results …

One of the first oral sessions of the conference included several presentations that should generate excited discussions. The first of these is for a new approach to an immune-based treatment called SB-728. Before anything else, it is important to recognise …

The 18th Conference on Retroviruses and Opportunistic Infections (CROI) is being held from 27 February – 3rd March 2011. This is the most important annual scientific HIV meeting. Online presentations Within a day or two, the conference puts all oral …

low level resistance – when there is some resistance but it does not have any significant impact on how well a drug works.  The HIV drug is still sensitve and is  considered active.

viral load – the amount of virus in a sample of blood or other fluid. With HIV this is commonly the amount of HIV in a millilitre (mL) of blood. See viral load test.

selective pressure – this is when a factor in the environment causes one type of organism to develop and grow in preference to another. With HIV drug resistance, the presence of a drug exerts selective pressure for resistance to develop. …

RNA – an abbreviation for the scientific word for genetic material found in some types of viruses. It is the abbreviation for ribonucleic acid. It is very similar to DNA but is single-strand rather than the double-strand in DNA. See …