HTB homepage • Conference reports • Articles by subject • Subscribe 30 July 2001 Contents Conference reports 5th International Workshop on HIV Drug Resistance, 4-8 June 2001, Scottsdale, Arizona Anti-HIV immune responses and partial viral suppression HIV resistance, phenotypic drug susceptibility and viral fitness SWATCH – alternating antiretroviral regimens Structured treatments interruptions Importance of additional active drugs for NNRTI-naive patients using NNRTI-based salvage regimens NNRTI and PI drug plasma levels are as critical as drug sensitivity in achieving treatment success in antiretroviral experienced patients Increased prevalence of transmission of drug resistant HIV and reduced response in newly infected subjects in nine US cities Role of codon-69 variants in reduced susceptibility to nucleoside analogues Selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug naive people Nucleoside resistance pathways may differ between HIV-1 and HIV-2 Role of Y318F mutation in NNRTI resistance Antiretrovirals T-20: will long-term use weaken the immune system’s ability to fight HIV? The steady-state pharmacokinetics of efavirenz and nevirapine when used in combination in human immunodeficiency virus type 1-infected persons Ritonavir approved in Europe as pharmacokinetic enhancer for use with other antiretrovirals Treatment access Abbott Labs cuts prices on many drugs, treatments amid pricing investigation Yale economist introduces proposal to settle debate between pharmaceutical companies and developing nations Kenyan lawmakers approve bill to suspend drug patent rights and improve cheaper drug access South African government issues first draft of legislation allowing importation of discounted pharmaceuticals International aid group to begin administering AIDS drugs to small group of poor South Africans Britain to Donate £75 million to global AIDS fund Uganda to offer free HIV drugs to pregnant women to prevent vertical HIV transmission Women's health HIV-positive women at high risk for pre-cancerous anal lesions Pregnancy Breastfeeding may increase maternal mortality among HIV-positive women, study shows Prevalence of the T215Y mutation in HIV type 1-infected pregnant women in a New York cohort, 1995-1999 PK and drug interactions A warning about milk thistle (silymarin) and drug interactions Side effects Sexual dysfunction associated with protease inhibitor containing HAART Nevirapine use linked to icteric hepatitis in some HIV-positive patients Tattoos flare up from HAART Treatment of hyperlipidemia in HIV-positive patients Cure-related research Thai officials call for cancellation of AIDS ‘miracle cure’ distribution amid controversy Basic science and immunology Immunologic profile of HIV-positive patients during viral remission and relapse on antiretroviral therapy Impaired replication of protease inhibitor-resistant HIV-1 in human thymus Basis of HIV resistance suggests new vaccine strategy Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS Other news African advocacy groups call for dismissal of USAID director Natsios after ‘racist comments’ Canada Reverses ban on entry of HIV-positive immigrants Bristol-Myers Squibb agrees to purchase DuPont’s drug business NEJM commemorates 20 years of AIDS with early-release retrospective New York’s Beth Israel Hospital making post-exposure HIV treatment available to general public On the web Strategies to cut risky sexual behaviour may do more harm than good ABC of AIDS – HIV infection and AIDS in the developing world Current review on hepatitis C virus in HIV/HCV coinfection ABC of AIDS – antiretroviral drugs HTB homepage • Conference reports • Articles by subject • Subscribe
