3 July 2007

Contents

Conference reports

• Treatment failure and tropism changes in maraviroc trial related to previously undetected CXCR4, rather than a mutational shift from CCR5

• Mechanisms of failure to CCR5 inhibitors is not explained by mutation in the V3 loop, cross-resistance between CCR5 inhibitors is likely

• Higher risk of resistance using lopinavir/r monotherapy

• Macaque study shows similar protection from rectal exposure using 2-hour pre- and 24-hour post exposure prophylaxis with tenofovir plus FTC compared to daily regimen

• Thirteen NNRTI mutations linked to resistance to etravirine (TMC-125)

• 14th Conference on Retroviruses and Opportunistic Infections, 25-28 February 2007, Los Angeles

• Protease inhibitors in pregnancy

• Low rates of HCV treatment among eligible injection drug users

• Effect of HCV and HIV on mortality among injecting drug users

• HCV/HIV-co-infected IDUs are at increased risk of death from hepatitis-related death in the HAART era, compared with HCV-mono-IDUs

• Long-term effectiveness of isoniazid prophylaxis on TB incidence in a cohort of IDUs

• The dynamics of HCV transmission among injection drug users in St. Petersburg

• “Founder effect” among HIV-positive IDU in Karachi, Pakistan

• 8th International Workshop on Clinical Pharmacology of HIV Therapy, April 2007, Budapest, Hungary

• Drug-drug interactions

• Pharmacokinetic data with existing antiretrovirals

• Antiretroviral pharmacokinetics in special patient populations

• Pharmacology of investigational drugs

Treatment access

• G8 pledges to Africa are insufficient

• Abbott sues ACT-UP Paris

• UK’s DFID support of Thailand

• Roche patent for hepatitis C drug challenged in India

Pregnancy

• Antiretroviral therapy and premature delivery in the United Kingdom and Ireland

• Early response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine

• Mother to child transmission during exclusive breastfeeding

• Surveillance of mother-to-child-transmission programmes: the case for universal screening

• Rapid progression in infants infected with HIV despite single dose nevirapine prophylaxis

Side effects

• 30 cases of atazanavir-related kidney stones reported

• Tenofovir and indinavir associated with increased risk of chronic renal failure in EuroSIDA study

Hepatitis coinfection

• Schering’s pegylated interferon approved for treating hepatitis C in HIV coinfected patients

Other news

• Campaign launched for HIV-positive people denied access to stay in the UK

On the web

• Meeting abstracts and reports

• Journal articles and online resources