February 2013

Contents

Editorial

• Volume 14 Number 1/2 January/February 2013

Treatment alerts

• WHO statement: generic antiretroviral therapy is safe and effective

Conference reports

• 3rd International Workshop on HIV and Women, 14-15 January 2013, Toronto

• Nevirapine-containing ART does not reduce combined oral contraceptive effectiveness

• Minimal risk of sexual HIV transmission for heterosexual couples when the HIV positive partner has an undetectable viral load

• Differences by age for women in response to initial ART: meta-analysis from clinical studies submitted to the FDA

• Lopinavir/ritonavir in pregnancy: results from a systematic review

• Possible mechanisms for adverse pregnancy outcomes in HIV positive women

• 43rd Union World Conference on Lung Health, 13-17 November 2012, Kuala Lumpur, Malaysia.

• Paediatric TB: glimpses of PK data and a potential new approach to drug development

Antiretrovirals

• Dolutegravir submitted to EU, US and Canadian regulatory agencies

• Darunavir: new oral suspension and 800 mg formulations approved in EU

• US label changes for rilpivirine and Eviplera follows EU caution on high baseline viral load: new summary on drug resistance

Treatment access

• New UNITAID grants focus on paediatric HIV, TB and malaria

• Global Fund results continue upward trend

• Germany extends €200 million annual support to Global Fund until 2016

• New analysis of country pledges and contributions to the Global Fund

• Renewal of Indian Global Fund Grant made conditional on government funding for ART

• MSF and DNDi report highlights importance of research into neglected diseases

Pregnancy

• The American Academy of Pediatrics recommends that HIV positive mothers not breastfeed their infants, regardless of maternal viral load and ART

Paediatric care

• US paediatric guidelines updated (November 2012)

Guidelines

• Implications if WHO guidelines increase CD4 threshold for starting ART to 500

Side effects

• Smoking is largest contributor to reduced life expectancy in Danish HIV cohort

• Low bone mineral density in MSM irrespective of HIV status

TB coinfection

• FDA approves bedaquiline for MDR TB: first new tuberculosis drug in half a century

• US fund additional $11 million for Xpert TB diagnostics in 14 countries

HIV prevention and transmission

• UK group describe risk of HIV transmission for people on effective ART as “extremely low”

• CDC issues brief on the prevention benefits of HIV treatment

• WHO recommendations for prevention and treatment of HIV for sex workers and their clients

Cure-related research

• Reports on cure research

Basic science and immunology

• Attack of the killer helpers (part two)

• Lymph node fibrosis, CD4 T cells and immune reconstitution

• New research on gut CD4 T-cell depletion and HIV pathogenesis

Other news

• “AllTrials” campaign for publication of full research results

On the web

• Conference abstracts

• RITA online: PrEP issue

• Poster on the immune response to HIV

• Free full text online articles from PLoS Medicine

PDFs

• Volume 14 Number 1/2 January/February 2013 PDF