May 2020

Contents

Editorial

• HIV and COVID-19: issue 3 (14 May 2020)

Guidelines

• New BHIVA guidelines: B/F/TAF now preferred first-line ART and reduced HIV monitoring in the UK during COVID-19

COVID-19: HIV and COVID-19 coinfection

• Higher rates of serious outcomes in HIV and COVID-19 coinfection in Germany: cautious review

• HIV is not linked to higher risk of COVID-19 in large New York cohort

• Case-studies show darunavir does not protect against CoV-2

COVID-19: treatment access

• COVID-19 could lead to 500,000 excess HIV-related deaths in sub-Saharan Africa linked to interruptions in ART supply

COVID-19: investigational drugs

• Remdesivir for COVID-19: randomised study shows similar antiviral effect to placebo

• Other remdesivir news: top results from NIH and Gilead studies – emergency approval in US and Japan

• Potential for tocilizumab to treat moderate to severe COVID-19

• Detectable viral load and IL-6: a role for tocilizumab or anti-JAK inhibitor baricitinib?

• Rheumatoid arthritis drug anakinra in small study to treat COVID-19

• Anticoagulants associated with improved survival rates in people hospitalised with COVID-19

• Monoclonal antibodies identified in convalescent plasma COVID-19

• Studies reporting lack of benefit from hydroxychloroquine to treat COVID-19

• Israeli cohort shows no protection against COVID-19 from childhood BCG vaccination

COVID-19: complications

• Obesity associated with worse outcomes in younger people hospitalised with COVID-19 in the US

• ACE inhibitors and angiotensin receptor blockers do not boost risk of COVID-19 or flu

• ACE inhibitors and angiotensin receptor blockers for hypertension tied to lower death risk with COVID-19

COVID-19: paediatrics

• Reports of Kawasaki-like disease in children after the start of the SARS-CoV-2 epidemic in Italy 

COVID-19: pathogenesis

• Potential for CoV-2 to be widely distributed in cells throughout the body

• Debate over development of pathogenic strains of CoV-2

COVID-19: guidelines

• Joint BHIVA/EACS update on HIV and COVID-19 (April 2020)

• Interim US guidance for coinfection COVID-19 and HIV

COVID-19: transmission & prevention

• Coronavirus: the risks – know them – avoid them

• Articles supporting wider use of face masks

COVID-19: other news

• US groups protest political cuts to COVID-19 research

COVID-19: on the web

• Guide to homecare and COVID-19

• Reviews on immunology of COVID-19

PDFs

• HIV and COVID-19 bulletin no 3 (14 May 2020)