May 2004

Contents

Editorial

• Volume 5 Number 4 May 2004

Conference reports

• 5th International Workshop on Clinical Pharmacology of HIV Therapy, 1-3 April 2004, Rome, Italy

• Large reductions in plasma PK levels of saquinavir, amprenavir and lopinavir/r levels when given with tipranavir/ritonavir

• Good generic drugs and good adherence in Rwanda

• Steady state PK of nelfinavir and M8 in pregnancy

• Higher nelfinavir concentrations improve response in children

• PK of once daily lopinavir/r in children

• 2nd European HIV Drug Resistance Workshop, 11-13 March 2004, Rome, Italy

• Understanding developments in HIV drug resistance for new drugs and targets — atazanavir, fusion (T-20) and receptor inhibitors

• 11th Conference on Retroviruses and Opportunistic Infections (CROI), 8-11 February 2004, San Francisco

• HIV-associated dementia and cognitive dysfunction

• Diabetes and HIV and HCV; aging/HIV and diabetes

Antiretrovirals

• US treatment guidelines updated – March 2004

• Atazanavir launched in UK

• Tenofovir/FTC co-formulation application made to EMEA

• Abacavir/3TC co-formulation available in expanded access

Treatment access

• Outcomes after two years of providing antiretrovirals in Khayelitsha, South Africa

• A round-up of news on access to treatments

Pregnancy

• Post partum complications in HIV-positive women

Paediatric care

• Children’s HIV National Network (CHINN) Review

• FDA approves new paediatric dose of nelfinavir

PK and drug interactions

• Eating grapefruit triggers statin-related rhabdomyolysis

Side effects

• FDA panel recommends approval of New-fill

• Lipodystrophy regresses in three patients switched to atazanavir

Cancer and HIV

• Surgery and HAART are an effective combination for treating HPV-associated lesions

Other news

• Postexposure prophylaxis does not lead to an increase in high-risk behaviour

• Law would permit HIV-positive organ donation

• A guide to applying to the Global Fund is released

On the web

• Conference reports

• Online medical training

• Newletters and journals

PDFs

• Volume 5 Number 4 May 2004 PDF