HTB

CROI 10 (Retrovirus) 2003

10th Conference on Retroviruses and Opportunistic Infections (CROI), 10-14 February 2003, Boston, USA

Pharmacokinetic papers from 10th CROI

Pediatric studies from 10th CROI

10th Conference on Retroviruses and Opportunistic Infections (CROI), 10-14 February 2003, Boston, USA

Pipeline compounds in Phase 2/3 Studies

96-week results show tenofovir-including regimen has side-effect advantages over d4T regimen in treatment naïve patients

2NN results – nevirapine and efavirenz in prospective randomised head-to-head study

NIH/NIAID study of generic drugs shows results consistent with stringent manufacturing standards

Treatment interruptions: cycles, pauses, are just plain stopping?

Conference has strong emphasis on women

Tenofovir and renal tubular dysfunction

Approaches to treatment of lipodystrophy

Surgery for buffalo hump shows variable results depending on method

Other studies – nucleosides and switching to abacavir; importance of lipoatrophy and buffalo hump

HAART to HEART: cardiovascular risk in HIV

Alendronate, vitamin D and calcium are safe and effective treatment for HIV-associated bone loss

Bone loss and fat loss are closely related in HIV patients on HAART

Low dose 200/100 IDV/RTV managed by TDM in substudy of co-infected patients

12-week response predicts which HIV-HCV coinfected patients will not benefit from continued pegylated interferon plus ribavirin

Pegylated interferon associated with eye disorders

Nevirapine resistance – the cautionary tales continue

10th Conference on Retroviruses and Opportunistic Infections, 10-14 February 2003, Boston, USA