Question
What are the side effects of TLD?
6 January 2022. Related: All topics, PEP/PEPSE, Side effects, Starting treatment.
Hi guys, I recently had sex with someone who was HIV positive. The next day I went to the clinic and they gave me PEP. I am currently on TLD but I am experiencing a stuffy nose, dry mouth and sore throat. I have little red spots on my legs, like a rash I don’t know if this are side effects or not. Please help.
Answer
Hi, how are you?
TLD is a combination medication. It includes dolutegravir, Lamivudine and tenofovir. As such any side effects are attributed to these medications. Stuffy nose, dry mouth and a sore throat are not a side effect. It is possible to cause a skin reaction and this should be checked by a doctor – the rash on your leg.
The common side effects for dolutegravir include: anxiety, depression, diarrhoea, fatigue, flatulence, stomach discomfort, headache, nausea, skin reactions, sleep disorders, vomiting.
The common side effects for lamivudine include: tummy pain, anaemia, lack of energy, diarrhoea, dizziness, fever, flatulence, headache, insomnia, nausea, low white blood cells, skin reactions, vomiting.
The common side effects for tenofovir include: abdominal pain, anaemia, tiredness, diarrhoea, dizziness, fever, flatulence, headache, insomnia, nausea, low white blood cells, skin reactions, vomiting.
These are the common side effects as listed by the BNF. You should note that while these are all common, they are not common together. It is also common for side effects to only be experienced in the first few weeks of starting medication while your body gets used to it. Common also means that it can be experienced by as few as 1 in 100 people.
Josh.
Hi Lucia, have you had these itching sores on your face for the month you have been taking TLD? and have you experienced sores like these before?
Hello.. I have a month now, taking TLD tablets, im now having this bad sores on my face, at times they are itching.. What can i do
Hi Faniswa, it is becoming very common for people to switch from older combinations to TLD. TLD is often much better tolerated by people with a far less side effect profile. Have you been able to speak with your doctor about potentially switching? It is possible that TLD would cause headaches but this is much less reported than older drugs. People also get used to TLD quickly and the side effects wear off. TLD does not increase urination.
Please follow this link for more information about TLD: https://i-base.info/guides/14970
Hi. Started using ARVs 2020. Im on tribus makes me pee alot and terrable headache most times and I only drink the tablet at night. Now I heared about TLD, more intrigued about it but I’m scared to be sick again as when I started the ARVs I was so sick, I had experienced most of the side effects.
Hi Bruce, while you are taking PEP it is recommended that you do not have sex without a condom. While you are on PEP you are unsure of your status. This can potentially put your partners at risk. If your partner is taking PrEP you do not need to use a condom as they will be protected.
I am in day 4 taking pep, can l have sex
Hi Edna, these symptoms are not caused by TLD. What is your blood pressure and how long have you noticed numbness on your face?
l start talking TLD two years ago, but am experiencing low blood pressure and numbness on my face.help
Hi Kay, do you know the name of the medication she is taking? How long after starting treatment did she start to experience these symptoms?
Someone close to me just start her arc meds she is having headache,fever and throwing up on her first day..is it normal?