May 2021

Contents

Editorial

• HTB: no. 5 – plus HIV and COVID-19 (3 May 2021)

• i-Base appeal: please support i-Base with £5 or £10 a month

In memory

• In memory: Paul Decle – community activist, gardener and friend

Early access

• HPV vaccine fails to prevent short-term recurrence of high grade lesions in HIV positive gay men

• Novavax reports 43% efficacy against B.1.351 South African variant but negative impact in HIV positive participants

• Oxford/AZ vaccine linked to 242 rare bloods clots in the UK: alternative recommended for people younger than 40

• Missed TB diagnoses during COVID-19 outbreaks despite prolonged respiratory symptoms

Conference reports

• Joint BHIVA/BASSH Spring Conference 2021

• BHIVA registry reports HIV is independently linked to worse presentation and outcomes from COVID-19

• HIV is linked to higher mortality from COVID-19 compared to HIV negative: 60% of deaths were black ethnicity

• Case-control study of HIV positive people hospitalised with COVID-19

Treatment access

• UK government to cut international HIV support to UNAIDS by 80%

Guidelines

• NICE guidelines on management of chronic pain: exercise but not opiods

COVID-19: HIV and COVID-19 coinfection

• US CDC includes HIV as medical criteria for priority to COVID-19 vaccines

• Review of research into SARS-CoV-2 and HIV coinfection

• Similar immune responses to the Oxford/AZ COVID vaccine reported In HIV positive and HIV negative participants

COVID-19: vaccine research

• Low responses to mRNA COVID-19 vaccines in those older than 80 vs <60 years and in recipients of solid organ transplants

• Two cases of viral breakthrough infections despite full protection from Pfizer mRNA vaccination

• US post-authorisation safety data on Pfizer and Moderna vaccines

• EMA review of Oxford/AZ vaccine and rare blood clots reported in the EU

• Interim results report 80% efficacy for India’s COVAXIN vaccine

• Three new COVID-19 vaccine studies enrolling in the UK

COVID-19: investigational drugs

• Dexamethasone: final results from RECOVERY study

• No impact from anakinra in mild/moderate COVID-19 pneumonia

COVID-19: long COVID

• Long COVID: studies reporting on long-term follow up on COVID-19

COVID-19: transmission & prevention

• Bar opening in the US: 100 guests linked to at least 46 cases of COVID-19

• Large sporting event in US linked to 649 cases of COVID-19

• Three carefully documented cases of SARS-CoV-2 transmission in a hospital setting despite masks

Future meetings

• Future meetings and webinars 2021

PDFs

• HTB: no.5 – plus HIV and COVID-19 (3 May 2021)