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Conference reports

Renal tubule damage with tenofovir despite normal glomerular function

10th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, 6-8 November 2008, London, UK

Report from the 10th IWADRLH by Jacqueline Capeau

Report from the 10th IWADRLH by Michael Dubé

Impact of body changes on the quality of life of HIV-positive treatment-experienced patients: an online community-based survey

48th Annual International Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 25-28 October 2008, Washington DC

Antiretroviral Pregnancy Registry finds no increase in congenital anomalies with exposure to tenofovir

No association between maternal antiretrovirals in pregnancy and congenital anomalies

Pharmacokinetics of saquinavir/ritonavir in pregnancy

Course of labour in pregnant HIV-positive women with no contraindication for vaginal delivery

Four weeks of antiretroviral prophylaxis is sufficient for HIV-exposed infants

HAART suppresses genital tract HIV shedding in HIV/HSV co-infected women

Efavirenz significantly reduces levels of some oral contraceptives

Lack of efficacy of isoniazid (INH) prophylaxis and PK evaluation in South African infants

48-week data for darunavir/ritonavir (DRV/r) in treatment-experienced children and adolescents

Greater lipodystrophy risk in older US children with low viral load

Studies of pipeline drugs: RDEA806, PRO140, bevirimat, elvucitabine

Maraviroc trial results reanalysed using more sensitive CCR5 tropism test

Other antiretroviral studies at ICAAC

High rate of rash in HIV negative volunteers combining raltegravir and darunavir

Bone loss in SMART study

Parathyroid hormone and vitamin D levels in patients using tenofovir

Haemoglobin A1c (HbA1c) may underestimate glycaemia in patients with diabetes on HIV therapy

Statin use in HIV-positive patients

HIV reinfection reported in 10% of couples in Zambian study

Drug interaction studies with approved drugs

Non alcoholic fatty liver disease (NAFLD) is common among HIV-positive patients

17th International AIDS Conference, 3-8 August 2008, Mexico City

Abacavir and heart disease: SMART study supports an abacavir-associated increased risk of cardiovascular disease

HAART use in pregnancy and preterm delivery and low birth weight

Reasons for mother to child transmission in England

New paediatric formulations of ARVs

3rd International Transmission Workshop, 1-2 August 2008, Mexico City

Intermittent tenofovir/FTC PrEP offers monkeys some protection

Tenofovir/FTC gel protects female monkeys from SHIV

Recently infected HIV-positive Quebec residents cause more than half of new cases

Common estimate of heterosexual HIV transmission risk sometimes far too low

10 key areas of research: non-technical summary of studies and presentations from Mexico

XVII International HIV Resistance Workshop (IHDRW), 6-10 June 2008, Sitges

Integrase inhibitor resistance and cross-resistance: weighing viral fitness and the option to benefit from second-generation compounds

Understanding etravirine susceptibility: new weighted genotype score and phenotypic cut-offs

Pipeline antiretrovirals: IDX899, CHX157 and bevirimat

Lack of virological impact of treatment intensification in suppressed patients supports latent viral reservoir as source of residual viraemia

NNRTI resistance in infants prophylaxed with single-dose nevirapine varies by the timing of infection

Detecting viral tropism: impact of a more sensitive Trofile (ES) assay

Low frequency K103N mutations are associated with poor virological response to NNRTI based therapy

14th Annual BHIVA Conference, 23-25 April 2008, Belfast

Bone problems raised in several UK studies

Late diagnosis in adolescence of vertically acquired HIV infection

Case study of multi-drug resistant woman receiving newer antiretroviral drugs in pregnancy

Predictors of treatment failure in Western Cape, South Africa

Late pregnancy loss in HIV-positive women

Renal tubular dysfunction with tenofovir-based HAART in four vertically infected adolescents

15th Conference on Retroviruses and Opportunistic Infections, Boston, 2-6 February 2008

The unmet need for contraception services for women receiving ART

Valacyclovir decreases plasma and genital viral loads in HSV-2/HIV-1 co-infected women

HPV genotypes in HIV-positive women in Zimbabwe and Uganda

14th Annual BHIVA Conference, 23-25 April 2008, Belfast

Overview of MRC studies in 2008

Initial results of BHIVA audit of HIV-related inpatient and day care in the UK

Monitoring patients on antiretroviral therapy in resource-limited settings with viral load, CD4 count, or clinical observation alone

Lower bilirubin increases in HCV-positive patients using atazanavir

Cases of ventricular tachycardia and atazanavir/r and methadone

Choice of ARVs for people after organ transplantation

Use of fibroscan as non-invasive alternative to liver biopsy in HCV/HIV coinfection

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